ID A0A2I1GA78_9GLOM Unreviewed; 634 AA. AC A0A2I1GA78; DT 28-FEB-2018, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 1. DT 22-FEB-2023, entry version 18. DE RecName: Full=Mitochondrial Rho GTPase {ECO:0000256|PIRNR:PIRNR037488}; DE EC=3.6.5.- {ECO:0000256|PIRNR:PIRNR037488}; GN ORFNames=RhiirA4_457518 {ECO:0000313|EMBL:PKY43522.1}; OS Rhizophagus irregularis. OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina; OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus. OX NCBI_TaxID=588596 {ECO:0000313|EMBL:PKY43522.1, ECO:0000313|Proteomes:UP000234323}; RN [1] {ECO:0000313|EMBL:PKY43522.1, ECO:0000313|Proteomes:UP000234323} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A4 {ECO:0000313|EMBL:PKY43522.1, RC ECO:0000313|Proteomes:UP000234323}; RA Ropars J., Sedzielewska K., Noel J., Charron P., Farinelli L., Marton T., RA Kruger M., Pelin A., Brachmann A., Corradi N.; RT "Genome analyses suggest a sexual origin of heterokaryosis in a supposedly RT ancient asexual fungus."; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mitochondrial GTPase involved in mitochondrial trafficking. CC Probably involved in control of anterograde transport of mitochondria CC and their subcellular distribution. {ECO:0000256|ARBA:ARBA00003481}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single- CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}. CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200, CC ECO:0000256|PIRNR:PIRNR037488}; Single-pass type IV membrane protein CC {ECO:0000256|ARBA:ARBA00004200, ECO:0000256|PIRNR:PIRNR037488}. CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family. CC {ECO:0000256|ARBA:ARBA00007981, ECO:0000256|PIRNR:PIRNR037488}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PKY43522.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LLXI01000259; PKY43522.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2I1GA78; -. DR VEuPathDB; FungiDB:FUN_004450; -. DR VEuPathDB; FungiDB:GLOIN_2v1578656; -. DR VEuPathDB; FungiDB:RhiirA1_334119; -. DR OrthoDB; 5481412at2759; -. DR Proteomes; UP000234323; Unassembled WGS sequence. DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR CDD; cd01893; Miro1; 1. DR CDD; cd01892; Miro2; 1. DR Gene3D; 1.10.238.10; EF-hand; 2. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR013566; EF_hand_assoc_1. DR InterPro; IPR013567; EF_hand_assoc_2. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR021181; Miro. DR InterPro; IPR020860; MIRO_dom. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR001806; Small_GTPase. DR InterPro; IPR003578; Small_GTPase_Rho. DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1. DR Pfam; PF08355; EF_assoc_1; 1. DR Pfam; PF08356; EF_assoc_2; 1. DR Pfam; PF00071; Ras; 2. DR PIRSF; PIRSF037488; Mt_Rho_GTPase; 1. DR PRINTS; PR00449; RASTRNSFRMNG. DR SMART; SM00054; EFh; 2. DR SMART; SM00175; RAB; 1. DR SMART; SM00173; RAS; 1. DR SMART; SM00174; RHO; 1. DR SUPFAM; SSF47473; EF-hand; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR TIGRFAMs; TIGR00231; small_GTP; 1. DR PROSITE; PS00018; EF_HAND_1; 1. DR PROSITE; PS50222; EF_HAND_2; 2. DR PROSITE; PS51423; MIRO; 2. DR PROSITE; PS51419; RAB; 1. DR PROSITE; PS51421; RAS; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR037488}; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRNR:PIRNR037488}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037488}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037488}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|PIRNR:PIRNR037488}; KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787, KW ECO:0000256|PIRNR:PIRNR037488}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|PIRNR:PIRNR037488}; KW Reference proteome {ECO:0000313|Proteomes:UP000234323}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 598..619 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 2..170 FT /note="Miro" FT /evidence="ECO:0000259|PROSITE:PS51423" FT DOMAIN 186..221 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 306..341 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 414..577 FT /note="Miro" FT /evidence="ECO:0000259|PROSITE:PS51423" SQ SEQUENCE 634 AA; 71269 MW; 8884F63D45D653A0 CRC64; MRREVRILLV GDDGVGKSTL ITSLIRETFV SELQHVVPEV TIPPEVTPEN VTTHIVDSSA RSDNREQLKT EIKKANVICI VYAIDNPHTF NRLASFWLPF IRSLGVNVPI VLVGNKIDLR GDQITNQSLE DEIIPIMNDF KEVETCVECS AKQPLNVSEV FYFAQKAVLH PTAPLYDSRE HVLKPACIEA LKRIFNLCDR DKDGVLNDDE LNEFQRKCFN APLQQQELEG VKEVVKEHEP AGVDDVGLTE LGFLFLHTLF IQRGRLETTW TVLRKFGYGD DLSLREDFLY PSFDVPHDCS VELSPLGYEF FTEIFQVFDK DKDGALKESE LAQLFSTSPG DPWANSDFPH TTITNDAGAV TLQGWLAQWS MTTLLDYKTT LSYLAYLGFE DDTRMALKVT RPRKADRKRN KVQRNVFLAY VFGAAGSGKT SLLKAFVNKP YTNGYTPTTR PFCAVNSVEI KGAEKYLVLQ EFGSKYEAEI LQNKRKMEAC DLLCFVFDSS DVNSFSYIVE LRKRHNLDNY PTVFVATKSD SDLVQQRNEV QPDVYCHDLG LSGPVSVSVK NHQTADLWNH LVGVAINPVP ATPGLAGSAH ESSKVKKYLT FTAVMGALGG AAFLGYRLYQ QQRGFGNISK RDIL //