ID A0A2H5WHE3_9BACT Unreviewed; 403 AA. AC A0A2H5WHE3; DT 28-FEB-2018, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 1. DT 12-AUG-2020, entry version 10. DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891}; DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891}; GN Name=topA {ECO:0000313|EMBL:GBC88352.1}; GN ORFNames=HRbin13_00473 {ECO:0000313|EMBL:GBC88352.1}; OS bacterium HR13. OC Bacteria. OX NCBI_TaxID=2035408 {ECO:0000313|EMBL:GBC88352.1, ECO:0000313|Proteomes:UP000236227}; RN [1] {ECO:0000313|Proteomes:UP000236227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Kato S., Suzuki K.; RT "Metaegenomics of thermophilic ammonia-oxidizing enrichment culture."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP-independent breakage of single-stranded DNA, followed by CC passage and rejoining.; EC=5.6.2.1; CC Evidence={ECO:0000256|ARBA:ARBA00000213}; CC -!- SIMILARITY: Belongs to the type IA topoisomerase family. CC {ECO:0000256|ARBA:ARBA00009446}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:GBC88352.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BEHP01000028; GBC88352.1; -; Genomic_DNA. DR Proteomes; UP000236227; Unassembled WGS sequence. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro. DR GO; GO:0006265; P:DNA topological change; IEA:InterPro. DR CDD; cd00186; TOP1Ac; 1. DR Gene3D; 1.10.290.10; -; 1. DR Gene3D; 1.10.460.10; -; 1. DR Gene3D; 2.70.20.10; -; 1. DR InterPro; IPR000380; Topo_IA. DR InterPro; IPR003601; Topo_IA_2. DR InterPro; IPR023406; Topo_IA_AS. DR InterPro; IPR013497; Topo_IA_cen. DR InterPro; IPR013824; Topo_IA_cen_sub1. DR InterPro; IPR013825; Topo_IA_cen_sub2. DR InterPro; IPR013826; Topo_IA_cen_sub3. DR InterPro; IPR023405; Topo_IA_core_domain. DR InterPro; IPR003602; Topo_IA_DNA-bd_dom. DR PANTHER; PTHR42785; PTHR42785; 1. DR Pfam; PF01131; Topoisom_bac; 1. DR PRINTS; PR00417; PRTPISMRASEI. DR SMART; SM00437; TOP1Ac; 1. DR SMART; SM00436; TOP1Bc; 1. DR SUPFAM; SSF56712; SSF56712; 1. DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:GBC88352.1}. FT DOMAIN 1..61 FT /note="TOP1Bc" FT /evidence="ECO:0000259|SMART:SM00436" FT DOMAIN 105..354 FT /note="TOP1Ac" FT /evidence="ECO:0000259|SMART:SM00437" SQ SEQUENCE 403 AA; 46983 MW; 8457757FE3BBA2EC CRC64; MSAQFSRRVL DRLIGYKLSP FLWRDLKERG LSVGRVQSPT LRLIVERERQ IQNFKRKKYY YIKAEFVVDG VEFSAVFKQR FEKPSNAEPF MKKLKDVMFV VKSVSKEMQK EPPPKPFNTV SLQAEASKIL GISVDKVQKM AQKLYEEGLI TYPRTDSYRM NKEKAQEFMK YIERTYGKDY VGRLRKYKEK ALAWGAHECI RPTSLNKKPE SVLELKLWSL ISSRALASLS SNAIREKVLV VLLPLSDHTL EFTAEGCLLV FDGWTRIYPK EVKDRALPHL EEGQVIKPRR VYIEEMEVPP PPRYTEGSLV KTLENLGIGR PSTYATIIKT LKDRGYVVLE KGYLKPTETA FKVVDYLMEK FPHLMDYGFT KYMEDNLDAV EEGKKDWKEV VRESYKRVLN AKE //