ID   A0A2G5WPA0_9BACL        Unreviewed;       347 AA.
AC   A0A2G5WPA0;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   28-FEB-2018, entry version 2.
DE   RecName: Full=Uroporphyrinogen decarboxylase {ECO:0000256|HAMAP-Rule:MF_00218, ECO:0000256|SAAS:SAAS00140866};
DE            Short=UPD {ECO:0000256|HAMAP-Rule:MF_00218};
DE            Short=URO-D {ECO:0000256|HAMAP-Rule:MF_00218};
DE            EC=4.1.1.37 {ECO:0000256|HAMAP-Rule:MF_00218, ECO:0000256|SAAS:SAAS00140860};
GN   Name=hemE {ECO:0000256|HAMAP-Rule:MF_00218};
GN   ORFNames=CSV78_15490 {ECO:0000313|EMBL:PIC65875.1};
OS   Sporosarcina sp. P16a.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Planococcaceae;
OC   Sporosarcina.
OX   NCBI_TaxID=2048262 {ECO:0000313|EMBL:PIC65875.1};
RN   [1] {ECO:0000313|EMBL:PIC65875.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P16a {ECO:0000313|EMBL:PIC65875.1};
RA   Oliver A., Kay M., Cooper K.;
RT   "Comparative genomics and methylomics between geographically and
RT   phenotypically diverse Sporosarcina species.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC       uroporphyrinogen-III to yield coproporphyrinogen-III.
CC       {ECO:0000256|HAMAP-Rule:MF_00218, ECO:0000256|SAAS:SAAS00140852}.
CC   -!- CATALYTIC ACTIVITY: Uroporphyrinogen III = coproporphyrinogen + 4
CC       CO(2). {ECO:0000256|HAMAP-Rule:MF_00218,
CC       ECO:0000256|SAAS:SAAS00140843}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 4/4. {ECO:0000256|HAMAP-Rule:MF_00218,
CC       ECO:0000256|SAAS:SAAS00378118}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00218,
CC       ECO:0000256|SAAS:SAAS00140867}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00218,
CC       ECO:0000256|SAAS:SAAS00140863}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00218, ECO:0000256|SAAS:SAAS00596275}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00218}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PIC65875.1}.
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DR   EMBL; PDYN01000030; PIC65875.1; -; Genomic_DNA.
DR   CDD; cd00717; URO-D; 1.
DR   HAMAP; MF_00218; URO_D; 1.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   Pfam; PF01208; URO-D; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00218,
KW   ECO:0000256|SAAS:SAAS00078189};
KW   Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00218,
KW   ECO:0000256|SAAS:SAAS00078199};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00218,
KW   ECO:0000256|SAAS:SAAS00078195};
KW   Porphyrin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00218,
KW   ECO:0000256|SAAS:SAAS00078185}.
FT   DOMAIN       21     30       Uroporphyrinogen_deCOase.
FT                                {ECO:0000259|PROSITE:PS00906}.
FT   DOMAIN      139    155       Uroporphyrinogen_deCOase.
FT                                {ECO:0000259|PROSITE:PS00907}.
FT   REGION       26     30       Substrate binding. {ECO:0000256|HAMAP-
FT                                Rule:MF_00218}.
FT   BINDING      75     75       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00218}.
FT   BINDING     151    151       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00218}.
FT   BINDING     206    206       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00218}.
FT   BINDING     319    319       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00218}.
FT   SITE         75     75       Transition state stabilizer.
FT                                {ECO:0000256|HAMAP-Rule:MF_00218}.
SQ   SEQUENCE   347 AA;  38746 MW;  6327C4D905B4DB90 CRC64;
     MSTFNDTLLR AARGEEIEHT PVWFMRQAGR SQPEYLKIKE KYSLEEITHQ PELCAYVTKL
     PVDQYDVDAA ILYKDIVTPL VGIGVDVKIK PGVGPVISNP IRSAQDIANL GEFSAEEQVP
     YVLDTIKMLT QEQLNVPLIG FAGAPFTLAS YMIEGGPSKS YNLTKSFMVS EPQAWFALMD
     KLADMTISYI QAQVNAGVKA VQIFDSWVGA LNVSDYRIFI KPTMTRIFSE LRKLNVPLIT
     FGVGASHLAN EWHDLPVDVV GLDWRLSIKE AGERGMTKPV QGNLDPSMLL ADWSVIEERA
     KLIVEQGVEH GSHIFNLGHG VFPQVQPATL KRLTAFVHEY SRELRSK
//