ID A0A2G2AEA4_9RHOB Unreviewed; 855 AA. AC A0A2G2AEA4; DT 31-JAN-2018, integrated into UniProtKB/TrEMBL. DT 31-JAN-2018, sequence version 1. DT 25-MAY-2022, entry version 17. DE RecName: Full=Glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134}; DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134}; DE Flags: Fragment; GN ORFNames=COB65_01270 {ECO:0000313|EMBL:PHQ86354.1}; OS Thalassobium sp. OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; OC Rhodobacteraceae; Thalassobium; unclassified Thalassobium. OX NCBI_TaxID=2030825 {ECO:0000313|EMBL:PHQ86354.1, ECO:0000313|Proteomes:UP000224118}; RN [1] {ECO:0000313|Proteomes:UP000224118} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.; RT "A dynamic microbial community with high functional redundancy inhabits the RT cold, oxic subseafloor aquifer."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The glycine cleavage system catalyzes the degradation of CC glycine. The P protein binds the alpha-amino group of glycine through CC its pyridoxal phosphate cofactor; CO(2) is released and the remaining CC methylamine moiety is then transferred to the lipoamide cofactor of the CC H protein. {ECO:0000256|ARBA:ARBA00003788}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + CC glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl- CC [glycine-cleavage complex H protein] + CO2; Xref=Rhea:RHEA:24304, CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, CC ChEBI:CHEBI:83143; EC=1.4.4.2; CC Evidence={ECO:0000256|ARBA:ARBA00001565}; CC -!- COFACTOR: CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; CC Evidence={ECO:0000256|ARBA:ARBA00001933, CC ECO:0000256|PIRSR:PIRSR603437-50}; CC -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P, CC T, L and H. {ECO:0000256|ARBA:ARBA00011690}. CC -!- SIMILARITY: Belongs to the GcvP family. CC {ECO:0000256|ARBA:ARBA00010756}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PHQ86354.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NVST01000015; PHQ86354.1; -; Genomic_DNA. DR Proteomes; UP000224118; Unassembled WGS sequence. DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC. DR GO; GO:0006546; P:glycine catabolic process; IEA:InterPro. DR CDD; cd00613; GDC-P; 1. DR Gene3D; 3.40.640.10; -; 2. DR Gene3D; 3.90.1150.10; -; 2. DR InterPro; IPR003437; GcvP. DR InterPro; IPR020581; GDC_P. DR InterPro; IPR015424; PyrdxlP-dep_Trfase. DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major. DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small. DR PANTHER; PTHR11773; PTHR11773; 1. DR Pfam; PF02347; GDC-P; 2. DR SUPFAM; SSF53383; SSF53383; 2. DR TIGRFAMs; TIGR00461; gcvP; 1. PE 3: Inferred from homology; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, KW ECO:0000313|EMBL:PHQ86354.1}; KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR603437-50}. FT MOD_RES 699 FT /note="N6-(pyridoxal phosphate)lysine" FT /evidence="ECO:0000256|PIRSR:PIRSR603437-50" FT NON_TER 855 FT /evidence="ECO:0000313|EMBL:PHQ86354.1" SQ SEQUENCE 855 AA; 93080 MW; A04BAB2FBB114D68 CRC64; MSFTPTDYLP YDFANRRHIG PSPAEMAQML EVIGVASLDQ LIDETVPKEI RQAEPLDFGK AKSERELLHH MRKVAGKNKV YTSLIGQGYY GTVTPPAIQR NILENPAWYT AYTPYQPEIS QGRLEALINF QTMIIDLTGL DIANASLLDE ATACAEAMVM AQRVAKSKAG AFFVDHHCHP QNIAVMQTRA APLGIKVIVG DPADMDPEAV FGAVFQYPGT YGAVHDFSDP IAALHGAKAI GIICADPLAL TLLKEPGAMG ADIAVGSTQR FGVPVGYGGP HAAYFACKDA YKRNMPGRIV GVSIDSHGHQ AYRLSLQTRE QHIRREKATS NVCTAQALLA VMASFYGVFH GPEGLKAIAQ RIHRKTVRLA KGLEEAGFDI GTGAFFDTIT VKVGKDQAKI MQAAVDRQIN LRRVGDDRIG ISLDETTRPK RVEKVWEAFG IKRKDRNFDP EYRVPDELHR TSDYLTHPVF HMNRAETEMM RYMRRLADRD LALDRAMIPL GSCTMKLNAA VEMMPVSWRE FSLVHPFAPR DQTEGYQELI TDLSAKLCEI TGYDAMSMQP NSGAQGEYAG LLTIAAYHRA NGDDQRKVCL IPVNAHGTNP ASAQMCGMEV VVVKCTERGD IDTEDFRAKA AAAGDTLAAC MITYPSTHGV FEETVREVCE ITHEFGGQVY LDGANLNAMV GLSKPGEIGS DVSHLNLHKT FCIPHGGGGP GMGPIGVKAH LAKHLPGHPQ TGGEQGPVSA APYGSPSILP ISWAYILLMG GAGLTQATRV AILNANYIAK RLEGAYDVLY KGTRGHVAHE CILDTRPYAD SAHVNVDDIA KRLMDCGFHA PTMSWPVAGT LMVEPTESET KAELD //