ID A0A2D7NQR3_9DELT Unreviewed; 471 AA. AC A0A2D7NQR3; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 05-DEC-2018, entry version 6. DE RecName: Full=Isochorismate synthase MenF {ECO:0000256|HAMAP-Rule:MF_01935}; DE EC=5.4.4.2 {ECO:0000256|HAMAP-Rule:MF_01935}; DE AltName: Full=Isochorismate mutase {ECO:0000256|HAMAP-Rule:MF_01935}; GN Name=menF {ECO:0000256|HAMAP-Rule:MF_01935}; GN ORFNames=CL937_06135 {ECO:0000313|EMBL:MAJ49269.1}; OS Deltaproteobacteria bacterium. OC Bacteria; Proteobacteria; Deltaproteobacteria. OX NCBI_TaxID=2026735 {ECO:0000313|EMBL:MAJ49269.1}; RN [1] {ECO:0000313|EMBL:MAJ49269.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MED631 {ECO:0000313|EMBL:MAJ49269.1}; RX PubMed=29337314; DOI=.1038/sdata.2017.203; RA Tully B.J., Graham E.D., Heidelberg J.F.; RT "The reconstruction of 2,631 draft metagenome-assembled genomes from RT the global oceans."; RL Sci. Data 5:170203-170203(2018). CC -!- FUNCTION: Catalyzes the conversion of chorismate to isochorismate. CC {ECO:0000256|HAMAP-Rule:MF_01935}. CC -!- CATALYTIC ACTIVITY: CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985, CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01935}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01935}; CC -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate CC biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step CC 1/7. {ECO:0000256|HAMAP-Rule:MF_01935}. CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. CC {ECO:0000256|HAMAP-Rule:MF_01935}. CC -!- SIMILARITY: Belongs to the isochorismate synthase family. CC {ECO:0000256|HAMAP-Rule:MF_01935}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:MAJ49269.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NZHX01000088; MAJ49269.1; -; Genomic_DNA. DR UniPathway; UPA00079; -. DR UniPathway; UPA01057; UER00163. DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.60.120.10; -; 1. DR HAMAP; MF_01935; MenF; 1. DR InterPro; IPR005801; ADC_synthase. DR InterPro; IPR015890; Chorismate_C. DR InterPro; IPR004561; IsoChor_synthase. DR InterPro; IPR034681; MenF. DR Pfam; PF00425; Chorismate_bind; 1. DR SUPFAM; SSF56322; SSF56322; 1. DR TIGRFAMs; TIGR00543; isochor_syn; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01935}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01935}; KW Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01935}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01935}. FT DOMAIN 208 460 Chorismate_bind. {ECO:0000259|Pfam: FT PF00425}. FT COILED 166 186 {ECO:0000256|SAM:Coils}. FT ACT_SITE 228 228 Proton acceptor. {ECO:0000256|HAMAP-Rule: FT MF_01935}. FT ACT_SITE 278 278 Proton donor. {ECO:0000256|HAMAP-Rule: FT MF_01935}. FT METAL 322 322 Magnesium. {ECO:0000256|HAMAP-Rule: FT MF_01935}. FT METAL 456 456 Magnesium. {ECO:0000256|HAMAP-Rule: FT MF_01935}. SQ SEQUENCE 471 AA; 53906 MW; 6C2902CBBE40510F CRC64; MLASPQTLDP KAPSTLSKAI EDLLEQLDQL GKGKLGTSLT GEGIIRLETK ASVEDPLSWL HTQKNNKKHF WREREGGETI AGVGECLVFE SEHGSTIELM LQRIRRLLNN SSDGVRIFGG IRFNLSSDSI SDEWKSWKQA RFVIPEIELI RDGKETRLAC NLNSVVLDKN RSLEGLRRRI SELSEEDSNN ILESNFQFLK KNHKPEYENW CDNVNQALSE IKSGTLNKIV LARKTEYQLQ EAYDPLKFLL RLRDRAPNAY QYCFQFDKDQ AWMGISPERL YKRQSRKIET EAVASTRPRG TNNEEDKNLA LELLQSQKEV REHDLVLERI ESVLNQFCDK ITRKSYREIL KLRQVQHLLS RIEGHLNPDH GESTLINAIH PTPAVCGIPD EKARLNIEQL ENFDRGWYAG PVGWISKNGA EFAVGIRSAQ IHHKTLRIYT GAGIVQGSDP DSEWNEIDAK LRNWESILEP A //