ID A0A2D7NQ86_9DELT Unreviewed; 339 AA. AC A0A2D7NQ86; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 25-MAY-2022, entry version 18. DE RecName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486, ECO:0000256|HAMAP-Rule:MF_00230}; DE Short=NN:DBI PRT {ECO:0000256|HAMAP-Rule:MF_00230}; DE EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991, ECO:0000256|HAMAP-Rule:MF_00230}; DE AltName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00030686, ECO:0000256|HAMAP-Rule:MF_00230}; GN Name=cobT {ECO:0000256|HAMAP-Rule:MF_00230, GN ECO:0000313|EMBL:MAJ49090.1}; GN ORFNames=CL937_05215 {ECO:0000313|EMBL:MAJ49090.1}; OS Deltaproteobacteria bacterium. OC Bacteria; Proteobacteria; Deltaproteobacteria. OX NCBI_TaxID=2026735 {ECO:0000313|EMBL:MAJ49090.1, ECO:0000313|Proteomes:UP000226880}; RN [1] {ECO:0000313|Proteomes:UP000226880} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Tully B.J., Graham E.D., Heidelberg J.F.; RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the RT Global Oceans."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from CC nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). CC {ECO:0000256|HAMAP-Rule:MF_00230}. CC -!- CATALYTIC ACTIVITY: CC Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = CC alpha-ribazole 5'-phosphate + H(+) + nicotinate; CC Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890, CC ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21; CC Evidence={ECO:0000256|ARBA:ARBA00001058, ECO:0000256|HAMAP- CC Rule:MF_00230}; CC -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha- CC ribazole from 5,6-dimethylbenzimidazole: step 1/2. CC {ECO:0000256|ARBA:ARBA00005049, ECO:0000256|HAMAP-Rule:MF_00230}. CC -!- SIMILARITY: Belongs to the CobT family. {ECO:0000256|ARBA:ARBA00007110, CC ECO:0000256|HAMAP-Rule:MF_00230}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:MAJ49090.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NZHX01000074; MAJ49090.1; -; Genomic_DNA. DR UniPathway; UPA00061; UER00516. DR Proteomes; UP000226880; Unassembled WGS sequence. DR GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd02439; DMB-PRT_CobT; 1. DR Gene3D; 1.10.1610.10; -; 1. DR Gene3D; 3.40.50.10210; -; 1. DR HAMAP; MF_00230; CobT; 1. DR InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase. DR InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact. DR InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N. DR InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf. DR Pfam; PF02277; DBI_PRT; 1. DR SUPFAM; SSF52733; SSF52733; 1. DR TIGRFAMs; TIGR03160; cobT_DBIPRT; 1. PE 3: Inferred from homology; KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP- KW Rule:MF_00230}; KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP- KW Rule:MF_00230}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_00230}. FT REGION 1..23 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 304 FT /note="Proton acceptor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00230" SQ SEQUENCE 339 AA; 35948 MW; 23EC4BA103B024ED CRC64; MNEELASPLQ SKVDGKTKPP GSLGDLEQLA LRIGLIQGTL EPQLKSPTML VFAGDHGITK EGVSPYPSEV TAQMVXNFLS GGAAINVFCR QHGXDLKVID AGVASDFEKH PLLVDEKIAX GTANFXXEKA MSENQAKECI SRGEKXAEEL PDXSCNVIGF GXMGIGNTSS SALXMHRXXG IXXESCVGRG TGLDDQGLSH KXXVLQEASE IHSGARGXIX VIAAFGGFEI AMMCGAMIAS SRXXRILLID GFXASTALLL AREMDPKVMD HAVFTHVSGE QGHRXLLEHL QVKPLLDLXL RLGEGTGAXL AYPLLVSAVA FXNXMASFES AGVSDRXDA //