ID A0A2D7NQ30_UNCDE Unreviewed; 244 AA. AC A0A2D7NQ30; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 22-FEB-2023, entry version 14. DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase {ECO:0000256|RuleBase:RU366074}; DE EC=1.1.1.100 {ECO:0000256|RuleBase:RU366074}; GN ORFNames=CL937_04920 {ECO:0000313|EMBL:MAJ49034.1}; OS Deltaproteobacteria bacterium. OC Bacteria; Proteobacteria; Deltaproteobacteria. OX NCBI_TaxID=2026735 {ECO:0000313|EMBL:MAJ49034.1, ECO:0000313|Proteomes:UP000226880}; RN [1] {ECO:0000313|Proteomes:UP000226880} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Tully B.J., Graham E.D., Heidelberg J.F.; RT "The Reconstruction of 2,631 Draft Metagenome-Assembled Genomes from the RT Global Oceans."; RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP CC substrates to beta-hydroxyacyl-ACP products, the first reductive step CC in the elongation cycle of fatty acid biosynthesis. CC {ECO:0000256|RuleBase:RU366074}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) CC + NADPH; Xref=Rhea:RHEA:17397, Rhea:RHEA-COMP:9916, Rhea:RHEA- CC COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, CC ChEBI:CHEBI:78776, ChEBI:CHEBI:78827; EC=1.1.1.100; CC Evidence={ECO:0000256|RuleBase:RU366074}; CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC {ECO:0000256|RuleBase:RU366074}. CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU366074}. CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) CC family. {ECO:0000256|RuleBase:RU366074}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:MAJ49034.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NZHX01000070; MAJ49034.1; -; Genomic_DNA. DR UniPathway; UPA00094; -. DR Proteomes; UP000226880; Unassembled WGS sequence. DR GO; GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:UniProtKB-UniRule. DR GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd05333; BKR_SDR_c; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR InterPro; IPR011284; 3oxo_ACP_reduc. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR020904; Sc_DH/Rdtase_CS. DR InterPro; IPR002347; SDR_fam. DR PANTHER; PTHR42879; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE; 1. DR PANTHER; PTHR42879:SF2; NADPH-DEPENDENT REDUCTASE BACG; 1. DR Pfam; PF13561; adh_short_C2; 1. DR PRINTS; PR00081; GDHRDH. DR PRINTS; PR00080; SDRFAMILY. DR SMART; SM00822; PKS_KR; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. DR TIGRFAMs; TIGR01830; 3oxo_ACP_reduc; 1. DR PROSITE; PS00061; ADH_SHORT; 1. PE 3: Inferred from homology; KW Fatty acid biosynthesis {ECO:0000256|RuleBase:RU366074}; KW Fatty acid metabolism {ECO:0000256|RuleBase:RU366074}; KW Lipid biosynthesis {ECO:0000256|RuleBase:RU366074}; KW Lipid metabolism {ECO:0000256|RuleBase:RU366074}; KW NADP {ECO:0000256|PIRSR:PIRSR611284-2, ECO:0000256|RuleBase:RU366074}; KW Oxidoreductase {ECO:0000256|RuleBase:RU366074}. FT ACT_SITE 153 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR611284-1, FT ECO:0000256|PROSITE-ProRule:PRU10001" FT BINDING 12..15 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT /evidence="ECO:0000256|PIRSR:PIRSR611284-2" FT BINDING 88 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT /evidence="ECO:0000256|PIRSR:PIRSR611284-2" FT BINDING 153..157 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT /evidence="ECO:0000256|PIRSR:PIRSR611284-2" FT BINDING 186 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT /evidence="ECO:0000256|PIRSR:PIRSR611284-2" SQ SEQUENCE 244 AA; 26231 MW; 9E9575DA43945280 CRC64; MGQEKKLALI TGAGRGIGKV IALQLAKSGA DIALTDLNPE LEDLKSELNK LGSKCLDFQV DVTDPEAIDK MVSEVVGSQG RIDILVNNAG ITQDNLMMRM KAEQWSKVXD VNLNGVFHIT RAVLKTMMKQ RSGKIISISS VVGFSGNPGQ VNYSSTKAAL VGFTKSLARE VGSRGITVNA VAPGFIDTAM TQALNETQQE EILRQIPLKR MGMPEDIAHA VDFLASEKAD YITGTVLHVN GGMY //