ID A0A2D7NPZ8_9DELT Unreviewed; 285 AA. AC A0A2D7NPZ8; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 07-NOV-2018, entry version 5. DE RecName: Full=Orotidine 5'-phosphate decarboxylase {ECO:0000256|HAMAP-Rule:MF_01215}; DE EC=4.1.1.23 {ECO:0000256|HAMAP-Rule:MF_01215}; DE AltName: Full=OMP decarboxylase {ECO:0000256|HAMAP-Rule:MF_01215}; DE Short=OMPDCase {ECO:0000256|HAMAP-Rule:MF_01215}; DE Short=OMPdecase {ECO:0000256|HAMAP-Rule:MF_01215}; GN Name=pyrF {ECO:0000256|HAMAP-Rule:MF_01215, GN ECO:0000313|EMBL:MAJ48998.1}; GN ORFNames=CL937_04735 {ECO:0000313|EMBL:MAJ48998.1}; OS Deltaproteobacteria bacterium. OC Bacteria; Proteobacteria; Deltaproteobacteria. OX NCBI_TaxID=2026735 {ECO:0000313|EMBL:MAJ48998.1}; RN [1] {ECO:0000313|EMBL:MAJ48998.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MED631 {ECO:0000313|EMBL:MAJ48998.1}; RX PubMed=29337314; DOI=.1038/sdata.2017.203; RA Tully B.J., Graham E.D., Heidelberg J.F.; RT "The reconstruction of 2,631 draft metagenome-assembled genomes from RT the global oceans."; RL Sci. Data 5:170203-170203(2018). CC -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2). CC {ECO:0000256|HAMAP-Rule:MF_01215, ECO:0000256|SAAS:SAAS00366387}. CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo CC pathway; UMP from orotate: step 2/2. {ECO:0000256|HAMAP- CC Rule:MF_01215, ECO:0000256|SAAS:SAAS00366392}. CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01215}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:MAJ48998.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NZHX01000067; MAJ48998.1; -; Genomic_DNA. DR UniPathway; UPA00070; UER00120. DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 3.20.20.70; -; 1. DR HAMAP; MF_01215; OMPdecase_type2; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR011995; OMPdecase_type-2. DR InterPro; IPR001754; OMPdeCOase_dom. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR PANTHER; PTHR43375; PTHR43375; 1. DR Pfam; PF00215; OMPdecase; 1. DR SMART; SM00934; OMPdecase; 1. DR SUPFAM; SSF51366; SSF51366; 1. DR TIGRFAMs; TIGR02127; pyrF_sub2; 1. PE 3: Inferred from homology; KW Decarboxylase {ECO:0000256|HAMAP-Rule:MF_01215, KW ECO:0000256|SAAS:SAAS00443888}; KW Lyase {ECO:0000256|HAMAP-Rule:MF_01215, KW ECO:0000256|SAAS:SAAS00054403}; KW Pyrimidine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01215, KW ECO:0000256|SAAS:SAAS00054395}. FT DOMAIN 17 247 OMPdecase. {ECO:0000259|SMART:SM00934}. FT ACT_SITE 94 94 Proton donor. {ECO:0000256|HAMAP-Rule: FT MF_01215}. SQ SEQUENCE 285 AA; 31744 MW; BF8E3833351862E1 CRC64; MNFLEKISNR FLRTNSHLCI GLDPDPQKIP EPFGKTPDQI FHFLDEVIEA TSEYALALKP NLAYFEALGL GGIRLFEKVL KTIPEDIPVI ADAKRGDIGP SSKKYAYALL EQFGCDAITV SPYMGYDSIE PFLNYKDKGI FVLCLTSNSG ANDFQVPNLY LQVAEKVREW NVHSNLGLVV GATHPERVLA IREKSGPMPF LIPGIGAQGG SLEKTLKAVQ DGTRVPCLIN ASRSILXPEK SXVFNXFKXT QEFSSKDCIS SSRHAAXELH QXIRNCLEKX WFXFN //