ID   A0A2C6KFH6_9APIC        Unreviewed;       224 AA.
AC   A0A2C6KFH6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-NOV-2024, entry version 31.
DE   SubName: Full=Root hair defective 3 gtp-binding protein {ECO:0000313|EMBL:PHJ15418.1};
GN   ORFNames=CSUI_010770 {ECO:0000313|EMBL:PHJ15418.1};
OS   Cystoisospora suis.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Cystoisospora.
OX   NCBI_TaxID=483139 {ECO:0000313|EMBL:PHJ15418.1, ECO:0000313|Proteomes:UP000221165};
RN   [1] {ECO:0000313|EMBL:PHJ15418.1, ECO:0000313|Proteomes:UP000221165}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wien I {ECO:0000313|EMBL:PHJ15418.1,
RC   ECO:0000313|Proteomes:UP000221165};
RX   PubMed=28161402; DOI=10.1016/j.ijpara.2016.11.007;
RA   Palmieri N., Shrestha A., Ruttkowski B., Beck T., Vogl C., Tomley F.,
RA   Blake D.P., Joachim A.;
RT   "The genome of the protozoan parasite Cystoisospora suis and a reverse
RT   vaccinology approach to identify vaccine candidates.";
RL   Int. J. Parasitol. 47:189-202(2017).
CC   -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC       maintaining the structure of the tubular endoplasmic reticulum network.
CC       {ECO:0000256|ARBA:ARBA00029381}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01052}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Very large inducible GTPase (VLIG) family.
CC       {ECO:0000256|ARBA:ARBA00006828}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PHJ15418.1}.
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DR   EMBL; MIGC01008244; PHJ15418.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2C6KFH6; -.
DR   VEuPathDB; ToxoDB:CSUI_010770; -.
DR   OrthoDB; 1606at2759; -.
DR   Proteomes; UP000221165; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:TreeGrafter.
DR   GO; GO:0016320; P:endoplasmic reticulum membrane fusion; IEA:TreeGrafter.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR030383; G_VLIG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008803; RHD3/Sey1.
DR   PANTHER; PTHR45923; PROTEIN SEY1; 1.
DR   PANTHER; PTHR45923:SF2; PROTEIN SEY1; 1.
DR   Pfam; PF05879; RHD3_GTPase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
DR   PROSITE; PS51717; G_VLIG; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221165}.
FT   DOMAIN          75..224
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51715"
FT   DOMAIN          75..224
FT                   /note="VLIG-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51717"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   224 AA;  24704 MW;  3C1F316207020597 CRC64;
     MELMNSPRTS SHQQGFSAPV PSSLLSPKEG ENNKKKKKHG EALDGGQLIQ IIDYEGDIVA
     DLDSWISKEK LRDVGFNFNV VTILGSQSSG KSSLMNALFG CNFQVMDHVH GHSQTTKGIW
     LGRDGFSRRL DENGIFSSSS SFSADSQGQE QPTLVVDVEG IDSRERGEDR QTFEHRSALF
     ALALADCLCI NVWYHSLGNF TASGYGLLKT VMQVNLELFA QQKK
//