ID A0A293MCD4_ORNER Unreviewed; 243 AA. AC A0A293MCD4; DT 20-DEC-2017, integrated into UniProtKB/TrEMBL. DT 20-DEC-2017, sequence version 1. DT 24-JUL-2024, entry version 16. DE RecName: Full=hypoxia-inducible factor-proline dioxygenase {ECO:0000256|ARBA:ARBA00039004}; DE EC=1.14.11.29 {ECO:0000256|ARBA:ARBA00039004}; DE Flags: Fragment; OS Ornithodoros erraticus (European soft tick) (Alectorobius erraticus). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; OC Parasitiformes; Ixodida; Ixodoidea; Argasidae; Ornithodorinae; OC Ornithodoros. OX NCBI_TaxID=265619 {ECO:0000313|EMBL:MAA38474.1}; RN [1] {ECO:0000313|EMBL:MAA38474.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Female {ECO:0000313|EMBL:MAA38474.1}; RC TISSUE=Gut {ECO:0000313|EMBL:MAA38474.1}; RA Oleaga A.; RT "Ornithodoros erraticus midgut genes differentially expressed after blood RT feeding."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha CC subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia- CC inducible factor alpha subunit]; Xref=Rhea:RHEA:48400, Rhea:RHEA- CC COMP:12093, Rhea:RHEA-COMP:12094, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, CC ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.29; CC Evidence={ECO:0000256|ARBA:ARBA00035981}; CC -!- COFACTOR: CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; CC Evidence={ECO:0000256|ARBA:ARBA00001961}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GFWV01013745; MAA38474.1; -; Transcribed_RNA. DR AlphaFoldDB; A0A293MCD4; -. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0008198; F:ferrous iron binding; IEA:TreeGrafter. DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro. DR GO; GO:0031545; F:peptidyl-proline 4-dioxygenase activity; IEA:TreeGrafter. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0071456; P:cellular response to hypoxia; IEA:TreeGrafter. DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1. DR InterPro; IPR051559; HIF_prolyl_hydroxylases. DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase. DR InterPro; IPR006620; Pro_4_hyd_alph. DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY. DR PANTHER; PTHR12907; EGL NINE HOMOLOG-RELATED; 1. DR PANTHER; PTHR12907:SF26; HIF PROLYL HYDROXYLASE, ISOFORM C; 1. DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1. DR SMART; SM00702; P4Hc; 1. DR PROSITE; PS51471; FE2OG_OXY; 1. PE 4: Predicted; KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964}; KW Iron {ECO:0000256|ARBA:ARBA00023004}; Kinase {ECO:0000313|EMBL:MAA38474.1}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Serine/threonine-protein kinase {ECO:0000313|EMBL:MAA38474.1}; KW Transferase {ECO:0000313|EMBL:MAA38474.1}. FT DOMAIN 103..205 FT /note="Fe2OG dioxygenase" FT /evidence="ECO:0000259|PROSITE:PS51471" FT NON_TER 243 FT /evidence="ECO:0000313|EMBL:MAA38474.1" SQ SEQUENCE 243 AA; 27854 MW; B35D3F76293ED5EA CRC64; MCRNVVNDMN QYGICVIDNF LGSVRGAAVL EEVKALYSSG MFRDGQLVNN REGSRGIVRG DRIIWLDGTE PGCPSIGFLV RTLDSIITRC TRNAKCGLLS QYNINQRTKA MIACYPGNST HYVKHVDNPN QDGRCITSIY YLNKNWDVKV HGGLLRMFPL GQESQVANIE PLFDRMLFFW SDRRNPHEVL PSFAVRFAIT VWYFDAEERK NALQKHQKGQ KQSQSYQQQA NILNPFIFSN YQQ //