ID   A0A288CG08_EHV4         Unreviewed;       496 AA.
AC   A0A288CG08;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   07-OCT-2020, entry version 14.
DE   RecName: Full=Virion host shutoff protein {ECO:0000256|ARBA:ARBA00018606};
GN   Name=19 {ECO:0000313|EMBL:AAC59533.1};
OS   Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10333 {ECO:0000313|Proteomes:UP000009245};
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=2839595;
RA   Cullinane A.A., Rixon F.J., Davison A.J.;
RT   "Characterization of the genome of equine herpesvirus 1 subtype 2.";
RL   J. Gen. Virol. 69:1575-1590(1988).
RN   [2] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=2915378;
RA   Riggio M.P., Cullinane A.A., Onions D.E.;
RT   "Identification and nucleotide sequence of the glycoprotein gB gene of
RT   equine herpesvirus 4.";
RL   J. Virol. 63:1123-1133(1989).
RN   [3] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=2167933;
RA   Nicolson L., Cullinane A.A., Onions D.E.;
RT   "The nucleotide sequence of an equine herpesvirus 4 gene homologue of the
RT   herpes simplex virus 1 glycoprotein H gene.";
RL   J. Gen. Virol. 71:1793-1800(1990).
RN   [4] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=2391500;
RA   Nicolson L., Cullinane A.A., Onions D.E.;
RT   "The nucleotide sequence of the equine herpesvirus 4 thymidine kinase
RT   gene.";
RL   J. Gen. Virol. 71:1801-1805(1990).
RN   [5] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=2171212; DOI=10.1016/0042-6822(90)90305-B;
RA   Nicolson L., Onions D.E.;
RT   "The nucleotide sequence of the equine herpesvirus 4 gC gene homologue.";
RL   Virology 179:378-387(1990).
RN   [6] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=1850013;
RA   Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P.,
RA   Meredith D.M.;
RT   "Antigenic and protein sequence homology between VP13/14, a herpes simplex
RT   virus type 1 tegument protein, and gp10, a glycoprotein of equine
RT   herpesvirus 1 and 4.";
RL   J. Virol. 65:2320-2326(1991).
RN   [7] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=8380320; DOI=10.1007/BF01309795;
RA   Nagesha H.S., Crabb B.S., Studdert M.J.;
RT   "Analysis of the nucleotide sequence of five genes at the left end of the
RT   unique short region of the equine herpesvirus 4 genome.";
RL   Arch. Virol. 128:143-154(1993).
RN   [8] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=8240007; DOI=10.1007/BF01309752;
RA   Riggio M.P., Onions D.E.;
RT   "DNA sequence of a gene cluster in the equine herpesvirus-4 genome which
RT   contains a newly identified herpesvirus gene encoding a membrane protein.";
RL   Arch. Virol. 133:171-178(1993).
RN   [9] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=8397286;
RA   Cullinane A.A., Neilan J., Wilson L., Davison A.J., Allen G.;
RT   "The DNA sequence of the equine herpesvirus 4 gene encoding glycoprotein
RT   gp17/18, the homologue of herpes simplex virus glycoprotein gD.";
RL   J. Gen. Virol. 74:1959-1964(1993).
RN   [10] {ECO:0000313|EMBL:AAC59533.1, ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=8206376; DOI=10.1016/0378-1119(94)90099-X;
RA   Riggio M.P., Onions D.E.;
RT   "Sequences of the ribonucleotide reductase-encoding genes of equine
RT   herpesvirus 4.";
RL   Gene 143:217-222(1994).
RN   [11] {ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=8259676; DOI=10.1006/viro.1994.1047;
RA   Purewal A.S., Allsopp R., Riggio M., Telford E.A., Azam S., Davison A.J.,
RA   Edington N.;
RT   "Equid herpesviruses 1 and 4 encode functional homologs of the herpes
RT   simplex virus type 1 virion transactivator protein, VP16.";
RL   Virology 198:385-389(1994).
RN   [12] {ECO:0000313|EMBL:AAC59533.1, ECO:0000313|Proteomes:UP000009245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1942 {ECO:0000313|Proteomes:UP000009245};
RX   PubMed=9603335;
RA   Telford E.A., Watson M.S., Perry J., Cullinane A.A., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-4.";
RL   J. Gen. Virol. 79:1197-1203(1998).
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC   -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC       {ECO:0000256|ARBA:ARBA00009669}.
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DR   EMBL; AF030027; AAC59533.1; -; Genomic_DNA.
DR   PIR; T42562; T42562.
DR   RefSeq; NP_045236.1; NC_001844.1.
DR   GeneID; 1487582; -.
DR   KEGG; vg:1487582; -.
DR   Proteomes; UP000009245; Genome.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR006086; XPG-I_dom.
DR   Pfam; PF00867; XPG_I; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023247};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW   Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          187..233
FT                   /note="XPGI"
FT                   /evidence="ECO:0000259|Pfam:PF00867"
FT   REGION          317..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  56313 MW;  0A992AD765905862 CRC64;
     MGLFGLLKYA YSNRLVKHDA ITTPPGIMTP IAIDLWNVMY TLMEKFEYDR SFPMDGAAVT
     AKCFFSLLRL LLKRSYYPIF VSDRGIYGDG RVKQGAKAIV SQTMSSYGGS GRISSSCFTG
     DEHDVELLEE YGETNGSTTQ PDICQPNETA TVCVEPARKC EHSSTRWSAL DGAPRLSYRL
     CVNLIRHLGY PYVNACNLEA DDVCANLYHT NTVAQIYTTD TDLILMGCDI ILDIMPLFPP
     TLRCCDVLMD LGVTYDEFLT EFVRCHTDLH ETQTLASVQS VIRSLYSPPD EDESTETQHA
     ISGHAWRCPK EKRGISWRRQ NDDYSGSSND DSDNSDSSDE DVACLSDRGC RYRERPAADT
     VNKRQGRRSI EASSRIVHLK YTSRYPPIME SAPRALVRMA PPKTRHEVLE RKFVKHVVSM
     LTPERRGALS IIRRLPITQE PSNFSLVHDT LKNLVSEHEI VRELANMFWN HIPTPTDYNT
     VLVNYWDDCG HRRQWS
//