ID   A0A287BSN5_PIG          Unreviewed;       498 AA.
AC   A0A287BSN5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   02-JUN-2021, entry version 23.
DE   SubName: Full=Zinc finger protein 446 {ECO:0000313|Ensembl:ENSSSCP00000059458};
GN   Name=ZNF446 {ECO:0000313|Ensembl:ENSSSCP00000059458,
GN   ECO:0000313|VGNC:VGNC:95241};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000059458, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000059458, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059458,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000059458}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEMK02000043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; A0A287BSN5; -.
DR   Ensembl; ENSSSCT00000055967; ENSSSCP00000059458; ENSSSCG00000039930.
DR   VGNC; VGNC:95241; ZNF446.
DR   GeneTree; ENSGT00940000162092; -.
DR   OMA; RRKPYTC; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; -; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR027768; Zfp446.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23226:SF210; PTHR23226:SF210; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00187}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          26..107
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000259|PROSITE:PS50804"
FT   DOMAIN          202..275
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   DOMAIN          397..424
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          443..470
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          471..498
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..297
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..395
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  53267 MW;  BEC22508832E17AA CRC64;
     MPSPLGPPSL PSLDSEATLE EPEAARQRFR GFCYQEAAGP HEALARLREL CHQWLQPEAH
     SKEQMLELLV LEQFLGALPP EIQAWVRGQR PGSPEEAAVL VEGLQHDPGQ LLSWITAHVL
     KRAVLPAAQK TEKSVRSSHP SEPVEPLRAA SGEGSNDAQM EGGAHPSCSV KEEPAGYGQE
     TAPSSPLNPA TSHERCLERQ EPTSAPFHPS RIQEEWGLLD PSQKELYWDV MLEKYGTVVS
     LGEEGPFSSR SCVCRASQGA PPSPARAPTP SLHVRTPHTP LVPGLPPDGP LTPAGLPRPL
     PEALAESEPE GLSPGPEGQR SLRPGKGPPA PGGWGRERGP GVAGDLALPR LPPAGESASS
     GAEGPSGRPG APPPAAWEGP SAAAAPPPPP PPRSKRYTCA QCGRAFDWKS VFVIHRRAHA
     NAPGAETPPQ APPRRAPPGP RSYSCEECGR SFSWKSQLVI HRKSHAGQRR HLCGDCGHSF
     DWKSQLVIHL KSHRPEAP
//