ID A0A271UD45_ECOLX Unreviewed; 265 AA. AC A0A271UD45; DT 20-DEC-2017, integrated into UniProtKB/TrEMBL. DT 20-DEC-2017, sequence version 1. DT 22-FEB-2023, entry version 26. DE RecName: Full=Protein MtfA {ECO:0000256|HAMAP-Rule:MF_01593}; DE AltName: Full=Mlc titration factor A {ECO:0000256|HAMAP-Rule:MF_01593}; GN Name=mtfA {ECO:0000256|HAMAP-Rule:MF_01593, GN ECO:0000313|EMBL:EFD0580167.1}; GN ORFNames=FFF58_02930 {ECO:0000313|EMBL:EFD0580167.1}, FKO60_01190 GN {ECO:0000313|EMBL:TZE52271.1}, HEP34_003772 GN {ECO:0000313|EMBL:EFM1447388.1}, HVZ71_09930 GN {ECO:0000313|EMBL:QLN27836.1}, TUM18780_17010 GN {ECO:0000313|EMBL:BCG36539.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:EFD0580167.1, ECO:0000313|Proteomes:UP000560684}; RN [1] {ECO:0000313|EMBL:EFD0580167.1, ECO:0000313|Proteomes:UP000560684} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CFSAN077272 {ECO:0000313|EMBL:EFD0580167.1, RC ECO:0000313|Proteomes:UP000560684}, and PSU-2464 RC {ECO:0000313|EMBL:EFM1447388.1, ECO:0000313|Proteomes:UP000519182}; RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback; RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:TZE52271.1, ECO:0000313|Proteomes:UP000324120} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=347 {ECO:0000313|EMBL:TZE52271.1, RC ECO:0000313|Proteomes:UP000324120}; RA Cormier A.C., Chalmer G., Cook S.R., Zaheer R., Hannon S.J., Booker C.W., RA Read R., Gow S.P., Mcallister T.A., Boerlin P.; RT "The presence and diversity of blaCTX-M among Escherichia coli from urban RT wastewater and feedlot cattle, in Alberta, Canada."; RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:QLN27836.1, ECO:0000313|Proteomes:UP000510644} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHB38-C13 {ECO:0000313|EMBL:QLN27836.1, RC ECO:0000313|Proteomes:UP000510644}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:BCG36539.1, ECO:0000313|Proteomes:UP000509260} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TUM18780 {ECO:0000313|EMBL:BCG36539.1, RC ECO:0000313|Proteomes:UP000509260}; RA Ito Y., Aoki K., Nakayama N., Ohtsuka M., Ota M., Kaneko N., Yoshida M., RA Ishii Y., Tateda K., Matsuse H.; RT "Whole-genome sequencing of blaNDM-5 positive Escherichia coli isolated RT from a Japanese patient with no history of travel abroad."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the regulation of ptsG expression by binding and CC inactivating Mlc. {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SUBUNIT: Interacts with Mlc. {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SIMILARITY: Belongs to the MtfA family. {ECO:0000256|HAMAP- CC Rule:MF_01593}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP023197; BCG36539.1; -; Genomic_DNA. DR EMBL; AASDQT010000001; EFD0580167.1; -; Genomic_DNA. DR EMBL; AATJYL010000038; EFM1447388.1; -; Genomic_DNA. DR EMBL; CP055624; QLN27836.1; -; Genomic_DNA. DR EMBL; VHKY01000001; TZE52271.1; -; Genomic_DNA. DR RefSeq; WP_001362605.1; NZ_WTSM01000001.1. DR EnsemblBacteria; PAR03876; PAR03876; BIU72_12200. DR Proteomes; UP000324120; Unassembled WGS sequence. DR Proteomes; UP000509260; Chromosome. DR Proteomes; UP000510644; Chromosome. DR Proteomes; UP000519182; Unassembled WGS sequence. DR Proteomes; UP000560684; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro. DR CDD; cd20169; Peptidase_M90_mtfA; 1. DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1. DR Gene3D; 1.10.472.150; Glucose-regulated metallo-peptidase M90, N-terminal domain; 1. DR HAMAP; MF_01593; MtfA; 1. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR010384; MtfA_fam. DR InterPro; IPR042252; MtfA_N. DR PANTHER; PTHR30164; MTFA PEPTIDASE; 1. DR PANTHER; PTHR30164:SF2; PROTEIN MTFA; 1. DR Pfam; PF06167; Peptidase_M90; 1. DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01593}. SQ SEQUENCE 265 AA; 30309 MW; 198E36659BBCF8A5 CRC64; MIKWPWKVQE SAHQTALPWQ EALSIPLLTC LTEQEQSKLV TLAERFLQQK RLVPLQGFEL DSLRSCRIAL LFCLPVLELG LEWLDGFHEV LIYPAPFVVD DEWEDDIGLV HNQRIVQSGQ SWQQGPIVLN WLDIQDSFDA SGFNLIIHEV AHKLDTRNGD RASGVPFIPL REVAGWEHDL HAAMNNIQEE IELVGENAAS IDAYAASDPA ECFAVLSEYF FSAPELFAPR FPSLWQRFCQ FYQQDPLQRL HHANDTDSFS TTNVH //