ID A0A271UD45_ECOLX Unreviewed; 265 AA. AC A0A271UD45; DT 20-DEC-2017, integrated into UniProtKB/TrEMBL. DT 20-DEC-2017, sequence version 1. DT 02-JUN-2021, entry version 20. DE RecName: Full=Protein MtfA {ECO:0000256|HAMAP-Rule:MF_01593}; DE AltName: Full=Mlc titration factor A {ECO:0000256|HAMAP-Rule:MF_01593}; GN Name=mtfA {ECO:0000256|HAMAP-Rule:MF_01593, GN ECO:0000313|EMBL:BCG36539.1}; GN ORFNames=BIU72_12200 {ECO:0000313|EMBL:PAR03876.1}, BON96_02635 GN {ECO:0000313|EMBL:TFA74100.1}, FKO60_01190 GN {ECO:0000313|EMBL:TZE52271.1}, G5697_23310 GN {ECO:0000313|EMBL:NGA93989.1}, GP720_02475 GN {ECO:0000313|EMBL:KAE9677730.1}, HNC80_01590 GN {ECO:0000313|EMBL:HAJ6677787.1}, HVW37_09675 GN {ECO:0000313|EMBL:QMO67173.1}, HVZ71_09930 GN {ECO:0000313|EMBL:QLN27836.1}, TUM18780_17010 GN {ECO:0000313|EMBL:BCG36539.1}; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562 {ECO:0000313|EMBL:PAR03876.1, ECO:0000313|Proteomes:UP000215625}; RN [1] {ECO:0000313|EMBL:TFA74100.1, ECO:0000313|Proteomes:UP000297344} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=2763-16 {ECO:0000313|EMBL:TFA74100.1, RC ECO:0000313|Proteomes:UP000297344}; RA Gumpert H., Hartung Hansen K., Bortolaia V., Jana B., Westh H., Agerso Y., RA Guardabassi L.; RT "Whole genome sequencing of CTX-M-14-producing Escherichia coli of animal RT and human origin: insights into dissemination of blaCTX-M-14."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:PAR03876.1, ECO:0000313|Proteomes:UP000215625} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GMR-RB-634 {ECO:0000313|EMBL:PAR03876.1, RC ECO:0000313|Proteomes:UP000215625}; RA Saavedra S.Y., Diaz L., Wiesner M., Correa A., Arevalo S.A., Reyes J., RA Hidalgo A.M., De La Cadena E., Perenguez M., Montano L.A., Ardila J., RA Rios R., Ovalle M.V., Diaz P., Porras P., Villegas M.V., Arias C.A., RA Castaneda E., Duarte C.; RT "Genomic and Molecular Characterization of Clinical Isolates of RT Enterobacteriaceae Harboring mcr-1 in Colombia, 2002-2016."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:HAJ6677787.1, ECO:0000313|Proteomes:UP000531682} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C1461 {ECO:0000313|EMBL:HAJ6677787.1}; RX PubMed=30286803; RA Souvorov A., Agarwala R., Lipman D.J.; RT "SKESA: strategic k-mer extension for scrupulous assemblies."; RL Genome Biol. 19:153-150(2018). RN [4] {ECO:0000313|EMBL:HAJ6677787.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C1461 {ECO:0000313|EMBL:HAJ6677787.1}; RG NCBI Pathogen Detection Project; RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:TZE52271.1, ECO:0000313|Proteomes:UP000324120} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=347 {ECO:0000313|EMBL:TZE52271.1, RC ECO:0000313|Proteomes:UP000324120}; RA Cormier A.C., Chalmer G., Cook S.R., Zaheer R., Hannon S.J., Booker C.W., RA Read R., Gow S.P., Mcallister T.A., Boerlin P.; RT "The presence and diversity of blaCTX-M among Escherichia coli from urban RT wastewater and feedlot cattle, in Alberta, Canada."; RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:KAE9677730.1, ECO:0000313|Proteomes:UP000434182} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TzEc076 {ECO:0000313|EMBL:KAE9677730.1, RC ECO:0000313|Proteomes:UP000434182}; RA Subbiah M., Call D.R.; RT "Antimicrobial-resistant enteric bacteria are widely distributed amongst RT people, animals and the environment in northern Tanzania."; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:NGA93989.1, ECO:0000313|Proteomes:UP000480356} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CAP43 {ECO:0000313|EMBL:NGA93989.1, RC ECO:0000313|Proteomes:UP000480356}; RA Castro V.S., Figueiredo E.S., Mcallister T., King R., Reuter T., Polo R.O., RA Conte-Junior C.A., Stanford K.; RT "Complete sequences of Escherichia coli O157 and non-O157 isolates from RT feces of Canadian feedlot cattle."; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|Proteomes:UP000510644, ECO:0000313|Proteomes:UP000514731} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RHB09-C24 {ECO:0000313|EMBL:QMO67173.1, RC ECO:0000313|Proteomes:UP000514731}, and RHB38-C13 RC {ECO:0000313|EMBL:QLN27836.1, ECO:0000313|Proteomes:UP000510644}; RA Shaw L.P.; RT "REHAB project genomes."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:BCG36539.1, ECO:0000313|Proteomes:UP000509260} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TUM18780 {ECO:0000313|EMBL:BCG36539.1, RC ECO:0000313|Proteomes:UP000509260}; RA Ito Y., Aoki K., Nakayama N., Ohtsuka M., Ota M., Kaneko N., Yoshida M., RA Ishii Y., Tateda K., Matsuse H.; RT "Whole-genome sequencing of blaNDM-5 positive Escherichia coli isolated RT from a Japanese patient with no history of travel abroad."; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the regulation of ptsG expression by binding and CC inactivating Mlc. {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SUBUNIT: Interacts with Mlc. {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01593}. CC -!- SIMILARITY: Belongs to the MtfA family. {ECO:0000256|HAMAP- CC Rule:MF_01593}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP023197; BCG36539.1; -; Genomic_DNA. DR EMBL; DABIBW010000001; HAJ6677787.1; -; Genomic_DNA. DR EMBL; WSGD01000001; KAE9677730.1; -; Genomic_DNA. DR EMBL; JAAKBO010000051; NGA93989.1; -; Genomic_DNA. DR EMBL; MVPO01000021; PAR03876.1; -; Genomic_DNA. DR EMBL; CP055624; QLN27836.1; -; Genomic_DNA. DR EMBL; CP057922; QMO67173.1; -; Genomic_DNA. DR EMBL; MTYD01000003; TFA74100.1; -; Genomic_DNA. DR EMBL; VHKY01000001; TZE52271.1; -; Genomic_DNA. DR RefSeq; WP_001362605.1; NZ_WTSM01000001.1. DR EnsemblBacteria; PAR03876; PAR03876; BIU72_12200. DR Proteomes; UP000215625; Unassembled WGS sequence. DR Proteomes; UP000297344; Unassembled WGS sequence. DR Proteomes; UP000324120; Unassembled WGS sequence. DR Proteomes; UP000434182; Unassembled WGS sequence. DR Proteomes; UP000480356; Unassembled WGS sequence. DR Proteomes; UP000509260; Chromosome. DR Proteomes; UP000510644; Chromosome. DR Proteomes; UP000514731; Chromosome. DR Proteomes; UP000531682; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro. DR CDD; cd20169; Peptidase_M90_mtfA; 1. DR Gene3D; 1.10.472.150; -; 1. DR Gene3D; 3.40.390.10; -; 1. DR HAMAP; MF_01593; MtfA; 1. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR010384; MtfA_fam. DR InterPro; IPR042252; MtfA_N. DR PANTHER; PTHR30164; PTHR30164; 1. DR Pfam; PF06167; Peptidase_M90; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01593}. SQ SEQUENCE 265 AA; 30309 MW; 198E36659BBCF8A5 CRC64; MIKWPWKVQE SAHQTALPWQ EALSIPLLTC LTEQEQSKLV TLAERFLQQK RLVPLQGFEL DSLRSCRIAL LFCLPVLELG LEWLDGFHEV LIYPAPFVVD DEWEDDIGLV HNQRIVQSGQ SWQQGPIVLN WLDIQDSFDA SGFNLIIHEV AHKLDTRNGD RASGVPFIPL REVAGWEHDL HAAMNNIQEE IELVGENAAS IDAYAASDPA ECFAVLSEYF FSAPELFAPR FPSLWQRFCQ FYQQDPLQRL HHANDTDSFS TTNVH //