ID   A0A259FGE0_9PROT        Unreviewed;       779 AA.
AC   A0A259FGE0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   05-FEB-2025, entry version 16.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:OZA37512.1};
GN   ORFNames=B7X87_10270 {ECO:0000313|EMBL:OZA37512.1};
OS   Hydrogenophilales bacterium 17-64-34.
OC   Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales.
OX   NCBI_TaxID=1970527 {ECO:0000313|EMBL:OZA37512.1, ECO:0000313|Proteomes:UP000216129};
RN   [1] {ECO:0000313|EMBL:OZA37512.1, ECO:0000313|Proteomes:UP000216129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17-64-34 {ECO:0000313|EMBL:OZA37512.1};
RA   Kantor R.S., Colenbrander Nelson T., Marshall S., Bennett D., Apte S.,
RA   Camacho D., Thomas B.C., Warren L.A., Banfield J.F.;
RT   "Lifting the veil on microbial sulfur biogeochemistry in mining
RT   wastewaters.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OZA37512.1}.
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DR   EMBL; NCIL01000008; OZA37512.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A259FGE0; -.
DR   Proteomes; UP000216129; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR052159; Competence_DNA_uptake.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        50..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        251..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        469..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          526..719
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   779 AA;  84853 MW;  6A35209A4AFF8A2A CRC64;
     MRFHLIAFCL GVFLLQLQAS LPPARALALL PLLTLVFLLP TGSSGQRGLR HAGVALLALA
     LGFAWAAWRA EMRLAERLPL HWQGVDIELV GVVVDLPQSN ARGERVLLRV ERILTPGVPN
     PGRVQLTRYA SRDGVRPAAM RAGERWQLTT RLKRPVGTHN PHGFDLEAWM LERGIGASGY
     VRESPPPERL DHLAATPVAW IAAARQTIRD RVFATLGDAP YAGVIAALTV GDQQSIPHDQ
     WRAFTRTGVN HLLSISGLHV TMIAALAGWG VMGIWRRWPR AVARWPARQA GLVAAVVAAV
     AYALLAGFQV PAQRTLFMLI VLAGAFWGRR EARPFSALIV AMSCVLLIDP WAVVSAGFWL
     SFGAMAAILW VTFGRVAAPR RLSGWVVAQA AVTLALAPAL WLLFQQVSLI SPLANAVAIP
     LVSWVVTPLA LLGVLVPPLW HLAAGLMAWL GEALQWASTL PWATLSRPAP GALATGLALI
     GAVWMLMPRG FPLRGLAWLL WLPLVWPAQD RIAPGEFVVE IIDVGQGTAV LIRTAHHALL
     YDTGPAFAES DAGERIVVPY LRASGVGRLD GVIVSHDDND HSGGLASVLR DMPTGWLLHA
     LPAGSAHLVA TPAPRRCVRG QRWHWDGVEF DMLNPRRSAW QDMTRKDNDF SCVLRVSRGT
     RSFLITGDAE RRGELELLES GQPLAATVLV AGHHGSRTSS LDAFVAEVSP RWVVYTVGYR
     NRFGHPHPQV TARFREAGSV QLRSDHGGLI RFRFGEAGVE AAQYAELPSR YWHAPSPHE
//