ID A0A256Y0P3_9EURY Unreviewed; 411 AA. AC A0A256Y0P3; DT 22-NOV-2017, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 1. DT 14-DEC-2022, entry version 11. DE RecName: Full=isocitrate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00013013}; DE EC=1.1.1.42 {ECO:0000256|ARBA:ARBA00013013}; GN ORFNames=B6U96_14045 {ECO:0000313|EMBL:OYT34023.1}; OS Archaeoglobales archaeon ex4484_92. OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales. OX NCBI_TaxID=2012529 {ECO:0000313|EMBL:OYT34023.1, ECO:0000313|Proteomes:UP000216673}; RN [1] {ECO:0000313|Proteomes:UP000216673} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Dombrowski N., Seitz K.W., Teske A., Baker B.; RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in RT hydrothermal sediment communities."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH; CC Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526, CC ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42; CC Evidence={ECO:0000256|ARBA:ARBA00023554}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OYT34023.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NJDI01000193; OYT34023.1; -; Genomic_DNA. DR AlphaFoldDB; A0A256Y0P3; -. DR Proteomes; UP000216673; Unassembled WGS sequence. DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC. DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS. DR InterPro; IPR004439; Isocitrate_DH_NADP_dimer_prok. DR InterPro; IPR024084; IsoPropMal-DH-like_dom. DR PANTHER; PTHR43504; ISOCITRATE DEHYDROGENASE [NADP]; 1. DR Pfam; PF00180; Iso_dh; 1. DR SMART; SM01329; Iso_dh; 1. DR TIGRFAMs; TIGR00183; prok_nadp_idh; 1. DR PROSITE; PS00470; IDH_IMDH; 1. PE 4: Predicted; KW Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435}; KW Oxidoreductase {ECO:0000313|EMBL:OYT34023.1}. FT DOMAIN 28..404 FT /note="Iso_dh" FT /evidence="ECO:0000259|SMART:SM01329" SQ SEQUENCE 411 AA; 45969 MW; 73B7138AE8C23716 CRC64; MYQKIVPPKD GEKIIFADDK LKVPDNPIIP YIVGDGIGKD VVPAAIKVID AAVKRIGKEI IWFRVYAGED AFKLYGNYLP QDTIDAIREF RVALKGPLTT PIGTGYRSLN VTLRQILDLY ANVRPIYYIE GIPSPINHPE KVNFVIFREN TEDVYSGIEF ERGSTEAIKL KKFLSEEFGI HIRDDAGIGI KPISEFATKR LVRMAIKYAI ENKRQSVTLV HKGNIMKYTE GAFRDWGYEV AIQEFGDYCI TEQELYQNYD GIRPKNKIVI KDRIADNMFQ QILTRTEEYD VIALPNLNGD YLSDAAAALI GGLGVAPGSN IGDGIGVFEP IHGSAPKYTG LGKVNPTAEI LTGCLMLEYI GWKEASDLIK RAIQMTIKDR IVTYDIHRHT GGKLVGTMEF ANAVIDNLET L //