ID A0A250Y4N1_CASCN Unreviewed; 733 AA. AC A0A250Y4N1; DT 22-NOV-2017, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 1. DT 12-SEP-2018, entry version 8. DE RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183}; DE EC=3.4.24.- {ECO:0000256|RuleBase:RU361183}; GN Name=BMP1 {ECO:0000313|EMBL:JAV38592.1}; OS Castor canadensis (Beaver). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; OC Castoridae; Castor. OX NCBI_TaxID=51338 {ECO:0000313|EMBL:JAV38592.1}; RN [1] {ECO:0000313|EMBL:JAV38592.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ROM106880 {ECO:0000313|EMBL:JAV38592.1}; RC TISSUE=Muscle {ECO:0000313|EMBL:JAV38592.1}; RX PubMed=28087693; DOI=.1534/g3.116.038208; RA Lok S., Paton T.A., Wang Z., Kaur G., Walker S., Yuen R.K., Sung W.W., RA Whitney J., Buchanan J.A., Trost B., Singh N., Apresto B., Chen N., RA Coole M., Dawson T.J., Ho K., Hu Z., Pullenayegum S., Samler K., RA Shipstone A., Tsoi F., Wang T., Pereira S.L., Rostami P., Ryan C.A., RA Tong A.H., Ng K., Sundaravadanam Y., Simpson J.T., Lim B.K., RA Engstrom M.D., Dutton C.J., Kerr K.C., Franke M., Rapley W., RA Wintle R.F., Scherer S.W.; RT "De Novo Genome and Transcriptome Assembly of the Canadian Beaver RT (Castor canadensis)."; RL G3 (Bethesda) 7:755-773(2017). CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU361183}; CC Note=Binds 1 zinc ion per subunit. CC {ECO:0000256|RuleBase:RU361183}; CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GFFV01001353; JAV38592.1; -; Transcribed_RNA. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd00041; CUB; 3. DR CDD; cd04281; ZnMc_BMP1_TLD; 1. DR Gene3D; 2.60.120.290; -; 3. DR Gene3D; 3.40.390.10; -; 1. DR InterPro; IPR015446; BMP_1/tolloid-like. DR InterPro; IPR000859; CUB_dom. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR001506; Peptidase_M12A. DR InterPro; IPR006026; Peptidase_Metallo. DR InterPro; IPR035914; Sperma_CUB_dom_sf. DR InterPro; IPR034036; ZnMP_TLD/BMP1. DR Pfam; PF01400; Astacin; 1. DR Pfam; PF00431; CUB; 3. DR PIRSF; PIRSF001199; BMP_1/tolloid-like; 1. DR PRINTS; PR00480; ASTACIN. DR SMART; SM00042; CUB; 3. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 1. DR SMART; SM00235; ZnMc; 1. DR SUPFAM; SSF49854; SSF49854; 3. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS01180; CUB; 3. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS01187; EGF_CA; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Hydrolase {ECO:0000256|RuleBase:RU361183, KW ECO:0000256|SAAS:SAAS00973787}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2, KW ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795}; KW Metalloprotease {ECO:0000256|RuleBase:RU361183, KW ECO:0000256|SAAS:SAAS01068076}; KW Protease {ECO:0000256|RuleBase:RU361183, KW ECO:0000256|SAAS:SAAS00973825}; KW Repeat {ECO:0000256|SAAS:SAAS00792548}; KW Signal {ECO:0000256|RuleBase:RU361183}; KW Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183, KW ECO:0000256|SAAS:SAAS00973802}. FT SIGNAL 1 27 {ECO:0000256|RuleBase:RU361183}. FT CHAIN 28 733 Metalloendopeptidase. FT {ECO:0000256|RuleBase:RU361183}. FT /FTId=PRO_5011819595. FT DOMAIN 325 437 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 438 550 CUB. {ECO:0000259|PROSITE:PS01180}. FT DOMAIN 550 591 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 594 706 CUB. {ECO:0000259|PROSITE:PS01180}. FT ACT_SITE 217 217 {ECO:0000256|PIRSR:PIRSR001199-1}. FT METAL 216 216 Zinc; catalytic. {ECO:0000256|PIRSR: FT PIRSR001199-2}. FT METAL 220 220 Zinc; catalytic. {ECO:0000256|PIRSR: FT PIRSR001199-2}. FT METAL 226 226 Zinc; catalytic. {ECO:0000256|PIRSR: FT PIRSR001199-2}. SQ SEQUENCE 733 AA; 83236 MW; 985DCC6104511FCE CRC64; MPGVARPPLP LLLRLLLLLL LPRPGRPLDL ADYTYDLGEE DASEPLNYKD PCKAAAFLGD IALDEEDLRA FQVQQAGDLR QRAACRSPIK AAGNSSAPSC QSTSGQSQRE TRGRWRGRPR SRRAATSRPE RVWPDGVIPF VIGGNFTGSQ RAVFRQAMRH WEKHTCVTFL ERTDEDSYIV FTYRPCGCCS YVGRRGGGPQ AISIGKNCDK FGIVVHELGH VIGFWHEHTR PDRDRHVSIV RENIQPGQEY NFLKMEIQEV ESLGETYDFD SIMHYARNTF SRGIFLDTIV PKYEVNGVKP PIGQRTRLSK GDIAQARKLY KCPACGETLQ DSTGNFSSPE YPNGYSAHMH CVWRISVTPG EKIILNFTSM DLYRSRLCWY DYVEVRDGFW RKAPLRGRFC GGKLPEPIVS TDSRLWVEFR SSSNWVGKGF FAVYEAICGG DVKKDNGHIQ SPNYPDDYRP NKVCIWRIQV SEGFHVGLTF QSFEIERHDS CAYDYLEVRD GHSESSSLIG RYCGYEKPDD IKSTSSRLWL KFVSDGSINK AGFAVNFFKE VDECSRPNRG GCEQRCLNTL GSYKCSCDPG YELAPDKRHC EAACGGFLTK LNGSITSPGW PKEYPPNKNC IWQLVAPTQY RISLQFDFFE TEGNDVCKYD FVEVRSGLTA DSKLHGKFCG SEKPEVITSQ YNNMRVEFKS DNTVSKKGFK AHFFSEKRPT LQPPRGRPQQ VKFRVQKRNR TPQ //