ID A0A224ANK2_HUMAN Unreviewed; 2843 AA. AC A0A224ANK2; DT 25-OCT-2017, integrated into UniProtKB/TrEMBL. DT 25-OCT-2017, sequence version 1. DT 05-JUN-2019, entry version 9. DE SubName: Full=Adenomatous polyposis coli protein isoform b {ECO:0000313|EMBL:BBA21111.1}; GN Name=APC {ECO:0000313|EMBL:BBA21111.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BBA21111.1}; RN [1] {ECO:0000313|EMBL:BBA21111.1} RP NUCLEOTIDE SEQUENCE. RA Tashiro J., Takahashi K., Matsubara Y., Miwa J., Arai M., Mishiro S.; RT "APC gene expressed in human colon."; RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC085427; BBA21111.1; -; mRNA. DR SMR; A0A224ANK2; -. DR ChiTaRS; APC; human. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro. DR GO; GO:0008017; F:microtubule binding; IEA:InterPro. DR GO; GO:0007050; P:cell cycle arrest; IEA:InterPro. DR GO; GO:0016477; P:cell migration; IEA:InterPro. DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro. DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro. DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro. DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro. DR Gene3D; 1.25.10.10; -; 1. DR InterPro; IPR026836; APC. DR InterPro; IPR009240; APC_15aa_rpt. DR InterPro; IPR009234; APC_basic_dom. DR InterPro; IPR026831; APC_dom. DR InterPro; IPR026818; Apc_fam. DR InterPro; IPR032038; APC_N. DR InterPro; IPR036149; APC_N_sf. DR InterPro; IPR041257; APC_rep. DR InterPro; IPR009223; APC_rpt. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000225; Armadillo. DR InterPro; IPR009232; EB1-bd. DR InterPro; IPR009224; SAMP. DR PANTHER; PTHR12607; PTHR12607; 1. DR PANTHER; PTHR12607:SF11; PTHR12607:SF11; 1. DR Pfam; PF05972; APC_15aa; 3. DR Pfam; PF05956; APC_basic; 1. DR Pfam; PF16689; APC_N_CC; 1. DR Pfam; PF05923; APC_r; 7. DR Pfam; PF18797; APC_rep; 1. DR Pfam; PF00514; Arm; 2. DR Pfam; PF05937; EB1_binding; 1. DR Pfam; PF05924; SAMP; 3. DR SMART; SM00185; ARM; 7. DR SUPFAM; SSF48371; SSF48371; 1. DR SUPFAM; SSF58050; SSF58050; 1. DR SUPFAM; SSF82931; SSF82931; 1. DR PROSITE; PS50176; ARM_REPEAT; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}. FT DOMAIN 4 55 APC_N_CC. {ECO:0000259|Pfam:PF16689}. FT REPEAT 660 702 ARM. {ECO:0000256|PROSITE-ProRule: FT PRU00259}. FT DOMAIN 2224 2575 APC_basic. {ECO:0000259|Pfam:PF05956}. FT DOMAIN 2670 2843 EB1_binding. {ECO:0000259|Pfam:PF05937}. FT REGION 239 305 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 828 878 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 923 943 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 958 987 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1099 1169 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1190 1244 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1311 1376 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1403 1475 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1526 1569 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1583 1611 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1663 1717 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1729 1852 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1878 1952 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 1965 2011 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 2043 2072 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 2147 2635 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 2667 2714 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT REGION 2729 2843 Disordered. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COILED 6 54 {ECO:0000256|SAM:Coils}. FT COILED 134 168 {ECO:0000256|SAM:Coils}. FT COILED 207 227 {ECO:0000256|SAM:Coils}. FT COILED 530 550 {ECO:0000256|SAM:Coils}. FT COMPBIAS 244 262 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 266 304 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 842 857 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 926 943 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 958 975 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1101 1130 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1132 1169 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1327 1350 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1357 1374 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1433 1447 Pro-rich. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1536 1562 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1680 1694 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1695 1712 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1749 1763 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1787 1832 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1878 1895 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1896 1938 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 1978 1995 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2170 2191 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2200 2225 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2234 2249 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2258 2426 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2461 2501 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2519 2533 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2557 2580 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2581 2596 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2617 2635 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2669 2686 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2697 2711 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2737 2813 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. FT COMPBIAS 2823 2843 Polar. {ECO:0000256|MobiDB-lite: FT A0A224ANK2}. SQ SEQUENCE 2843 AA; 311662 MW; 2079F4AE4A90A281 CRC64; MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR RGFVNGSRES TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRIAR IQQIEKDILR IRQLLQSQAT EAERSSQNKH ETGSHDAERQ NEGQGVGEIN MATSGNGQGS TTRMDHETAS VLSSSSTHSA PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC WEWQEAHEPG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG GLQAIAELLQ VDCEMYGLTN DHYSITLRRY AGMALTNLTF GDVANKATLC SMKGCMRALV AQLKSESEDL QQVIASVLRN LSWRADVNSK KTLREVGSVK ALMECALEVK KESTLKSVLS ALWNLSAHCT ENKADICAVD GALAFLVGTL TYRSQTNTLA IIESGGGILR NVSSLIATNE DHRQILRENN CLQTLLQHLK SHSLTIVSNA CGTLWNLSAR NPKDQEALWD MGAVSMLKNL IHSKHKMIAM GSAAALRNLM ANRPAKYKDA NIMSPGSSLP SLHVRKQKAL EAELDAQHLS ETFDNIDNLS PKASHRSKQR HKQSLYGDYV FDTNRHDDNR SDNFNTGNMT VLSPYLNTTV LPSSSSSRGS LDSSRSEKDR SLERERGIGL GNYHPATENP GTSSKRGLQI STTAAQIAKV MEEVSAIHTS QEDRSSGSTT ELHCVTDERN ALRRSSAAHT HSNTYNFTKS ENSNRTCSMP YAKLEYKRSS NDSLNSVSSS DGYGKRGQMK PSIESYSEDD ESKFCSYGQY PADLAHKIHS ANHMDDNDGE LDTPINYSLK YSDEQLNSGR QSPSQNERWA RPKHIIEDEI KQSEQRQSRN QSTTYPVYTE STDDKHLKFQ PHFGQQECVS PYRSRGANGS ETNRVGSNHG INQNVSQSLC QEDDYEDDKP TNYSERYSEE EQHEEEERPT NYSIKYNEEK RHVDQPIDYS LKYATDIPSS QKQSFSFSKS SSGQSSKTEH MSSSSENTST PSSNAKRQNQ LHPSSAQSRS GQPQKAATCK VSSINQETIQ TYCVEDTPIC FSRCSSLSSL SSAEDEIGCN QTTQEADSAN TLQIAEIKEK IGTRSAEDPV SEVPAVSQHP RTKSSRLQGS SLSSESARHK AVEFSSGAKS PSKSGAQTPK SPPEHYVQET PLMFSRCTSV SSLDSFESRS IASSVQSEPC SGMVSGIISP SDLPDSPGQT MPPSRSKTPP PPPQTAQTKR EVPKNKAPTA EKRESGPKQA AVNAAVQRVQ VLPDADTLLH FATESTPDGF SCSSSLSALS LDEPFIQKDV ELRIMPPVQE NDNGNETESE QPKESNENQE KEAEKTIDSE KDLLDDSDDD DIEILEECII SAMPTKSSRK AKKPAQTASK LPPPVARKPS QLPVYKLLPS QNRLQPQKHV SFTPGDDMPR VYCVEGTPIN FSTATSLSDL TIESPPNELA AGEGVRGGAQ SGEFEKRDTI PTEGRSTDEA QGGKTSSVTI PELDDNKAEE GDILAECINS AMPKGKSHKP FRVKKIMDQV QQASASSSAP NKNQLDGKKK KPTSPVKPIP QNTEYRTRVR KNADSKNNLN AERVFSDNKD SKKQNLKNNS KDFNDKLPNN EDRVRGSFAF DSPHHYTPIE GTPYCFSRND SLSSLDFDDD DVDLSREKAE LRKAKENKES EAKVTSHTEL TSNQQSANKT QAIAKQPINR GQPKPILQKQ STFPQSSKDI PDRGAATDEK LQNFAIENTP VCFSHNSSLS SLSDIDQENN NKENEPIKET EPPDSQGEPS KPQASGYAPK SFHVEDTPVC FSRNSSLSSL SIDSEDDLLQ ECISSAMPKK KKPSRLKGDN EKHSPRNMGG ILGEDLTLDL KDIQRPDSEH GLSPDSENFD WKAIQEGANS IVSSLHQAAA AACLSRQASS DSDSILSLKS GISLGSPFHL TPDQEEKPFT SNKGPRILKP GEKSTLETKK IESESKGIKG GKKVYKSLIT GKVRSNSEIS GQMKQPLQAN MPSISRGRTM IHIPGVRNSS SSTSPVSKKG PPLKTPASKS PSEGQTATTS PRGAKPSVKS ELSPVARQTS QIGGSSKAPS RSGSRDSTPS RPAQQPLSRP IQSPGRNSIS PGRNGISPPN KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQMSQQNLTK QTGLSKNASS IPRSESASKG LNQMNNGNGA NKKVELSRMS STKSSGSESD RSERPVLVRQ STFIKEAPSP TLRRKLEESA SFESLSPSSR PASPTRSQAQ TPVLSPSLPD MSLSTHSSVQ AGGWRKLPPN LSPTIEYNDG RPAKRHDIAR SHSESPSRLP INRSGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES SEKAKSEDEK HVNSISGTKQ SKENQVSAKG TWRKIKENEF SPTNSTSQTV SSGATNGAES KTLIYQMAPA VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKA NPNIKDSKDN QAKQNVGNGS VPMRTVGLEN RLNSFIQVDA PDQKGTEIKP GQNNPVPVSE TNESSIVERT PFSSSSSSKH SSPSGTVAAR VTPFNYNPSP RKSSADSTSA RPSQIPTPVN NNTKKRDSKT DSTESSGTQS PKRHSGSYLV TSV //