ID A0A1Y9TFM3_TACFU Unreviewed; 753 AA. AC A0A1Y9TFM3; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 03-MAY-2023, entry version 21. DE SubName: Full=Toll-like receptor 19 {ECO:0000313|EMBL:AQY78352.1}; DE Flags: Fragment; OS Tachysurus fulvidraco (Yellow catfish) (Pimelodus fulvidraco). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Bagridae; Tachysurus. OX NCBI_TaxID=1234273 {ECO:0000313|EMBL:AQY78352.1}; RN [1] {ECO:0000313|EMBL:AQY78352.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28546018; DOI=10.1016/j.fsi.2017.05.056; RA Wang K.L., Ji W., Zhang G.R., Wei K.J., Shi Z.C., Zhang X.T., Zheng H., RA Fan Q.X.; RT "Molecular characterization and expression analysis of three TLR genes in RT yellow catfish (Pelteobagrus fulvidraco): Responses to stimulation of RT Aeromonas hydrophila and TLR ligands."; RL Fish Shellfish Immunol. 66:466-479(2017). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the Toll-like receptor family. CC {ECO:0000256|ARBA:ARBA00009634}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY123646; AQY78352.1; -; mRNA. DR AlphaFoldDB; A0A1Y9TFM3; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3. DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR017241; Toll-like_receptor. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1. DR PANTHER; PTHR24365:SF522; TOLL-LIKE RECEPTOR 13; 1. DR Pfam; PF13855; LRR_8; 1. DR Pfam; PF01582; TIR; 1. DR PIRSF; PIRSF037595; Toll-like_receptor; 5. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52058; L domain-like; 2. DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1. DR PROSITE; PS51450; LRR; 1. DR PROSITE; PS50104; TIR; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}; KW Innate immunity {ECO:0000256|ARBA:ARBA00022588}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AQY78352.1}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 541..561 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 602..745 FT /note="TIR" FT /evidence="ECO:0000259|PROSITE:PS50104" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AQY78352.1" SQ SEQUENCE 753 AA; 87591 MW; 6E8E481DB0BF8405 CRC64; MIGLKYLEVI NSDLTSIGNR GCTSWPLAVL AGIQDLNLGN NSIKKIVAQS LAVFQNLSSF SLGYYGVWLG EIWESGVGKV SELSMSGSVN KEYPTNCKEM CQLVFNLNLH SLEISYFHLD SLSMEDLKDC GKELRVLSIY NTKVQQLDPG FWKSMAGLQT VNLVHMELTE ASFCVAANGT VWNVTTLNLS RNRLTVVKTH QFVCTPRLEQ LLLKGNMITT LEPEAFSGLR HLKILNLDSN KIKILSAYDF LSLRSLEVLL LGGNVIEKIE NGIFRNQREL RELAFGRLEY VYVLNLNLLF YGIPENIQRL SIDAYVGTTI YFGNTGRPKE SFIFELNGGQ LTFGDKYPPF LESVRELKLS GNVFYFKTDF FLPYFSHLES LELTGNPEQL YMNYTAISDL RYLKRLKLIN LNFLNLPDPS MTFWNLDQLQ ILVLHNCRLN FMTKRMFRDL HSLELLYLHS DNPLMLQDGM FDAMPVLRAV VIDKLVFQCD CQTGWFLEWA QNTRTEVINL PQQQCVWHYQ KLNLLSTMEK LCQTDMQYLC YLGTITIISL LLVSAITYRF AYWPFMVLVF RLRGYLERNF GKAWKRRKQG YRGVDLEAEE DMKYDAFVSF SHRDEAWVFE EMAPRLEEQG QPRLRLCLHN RDFEVGKGII DNIAESIYSS RRTVCVLSRQ YLRSDWCGLE MRVATHRLLE EQKHRLILVF LEHISPFELS TFHRLAKLVK THTYLDWPRD NAEKTYFWER LRRNIAEEEM DAQ //