ID A0A1Y1C2J3_SINJA Unreviewed; 213 AA. AC A0A1Y1C2J3; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 08-MAY-2019, entry version 6. DE RecName: Full=Neurotrophin-3 {ECO:0000256|RuleBase:RU365037}; DE Short=NT-3 {ECO:0000256|RuleBase:RU365037}; DE Flags: Fragment; GN Name=NT3 {ECO:0000313|EMBL:BAX64237.1}; OS Sinomicrurus japonicus japonicus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Sinomicrurus. OX NCBI_TaxID=1761978 {ECO:0000313|EMBL:BAX64237.1}; RN [1] {ECO:0000313|EMBL:BAX64237.1} RP NUCLEOTIDE SEQUENCE. RA Kaito T., Ota H., Toda M.; RT "The evolutionary history and taxonomic reevaluation of the Japanese RT coral snake, Sinomicrurus japonicus (Serpentes, Elapidae), endemic to RT the Ryukyu Archipelago, Japan, by use of molecular and morphological RT analyses."; RL J. Zool. Syst. Evol. Res. 55:156-166(2017). CC -!- FUNCTION: Seems to promote the survival of visceral and CC proprioceptive sensory neurons. {ECO:0000256|RuleBase:RU365037}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU365037}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|RuleBase:RU365037, ECO:0000256|SAAS:SAAS00543519}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC094139; BAX64237.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR InterPro; IPR015578; Neurotrophin-3. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00426825}; KW Growth factor {ECO:0000256|RuleBase:RU365037, KW ECO:0000256|SAAS:SAAS00160138}; KW Secreted {ECO:0000256|RuleBase:RU365037}. FT DOMAIN 131 213 NGF. {ECO:0000259|SMART:SM00140}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAX64237.1}. FT NON_TER 213 213 {ECO:0000313|EMBL:BAX64237.1}. SQ SEQUENCE 213 AA; 23828 MW; 156F1890CAB06CEA CRC64; LAFLSGIQST SMDQGSLSED SMNSFLKTLI QAGIWKNTIP KQGARTKDGG PTAGRKTEAR PELTTSQDTK LGLQPVVSLD AEFLRQQRRF SSPRVLLSEN TPLEPPPLYV MEEPLALNRT SRRKRYTEGK THRGEYSVCD SESRWVTDKT SAVDIRGHQV TVLGEIRMGP SPVKQYFXET RCKQAKPAKS GCRGIDDKHW NSQCKTSQTF VRA //