ID A0A1Y1C2J3_SINJA Unreviewed; 213 AA. AC A0A1Y1C2J3; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 02-DEC-2020, entry version 13. DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037}; DE Short=NT-3 {ECO:0000256|RuleBase:RU365037}; DE Flags: Fragment; GN Name=NT3 {ECO:0000313|EMBL:BAX64237.1}; OS Sinomicrurus japonicus japonicus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; OC Serpentes; Colubroidea; Elapidae; Elapinae; Sinomicrurus. OX NCBI_TaxID=1761978 {ECO:0000313|EMBL:BAX64237.1}; RN [1] {ECO:0000313|EMBL:BAX64237.1} RP NUCLEOTIDE SEQUENCE. RA Kaito T., Ota H., Toda M.; RT "The evolutionary history and taxonomic reevaluation of the Japanese coral RT snake, Sinomicrurus japonicus (Serpentes, Elapidae), endemic to the Ryukyu RT Archipelago, Japan, by use of molecular and morphological analyses."; RL J. Zool. Syst. Evol. Res. 55:156-166(2017). CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312, CC ECO:0000256|RuleBase:RU365037}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU365037}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC094139; BAX64237.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR InterPro; IPR015578; Neurotrophin-3. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF4; PTHR11589:SF4; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00248; NGF_1; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030, KW ECO:0000256|RuleBase:RU365037}; Secreted {ECO:0000256|RuleBase:RU365037}; KW Toxin {ECO:0000256|ARBA:ARBA00022656}. FT DOMAIN 131..213 FT /note="NGF" FT /evidence="ECO:0000259|SMART:SM00140" FT REGION 40..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAX64237.1" FT NON_TER 213 FT /evidence="ECO:0000313|EMBL:BAX64237.1" SQ SEQUENCE 213 AA; 23828 MW; 156F1890CAB06CEA CRC64; LAFLSGIQST SMDQGSLSED SMNSFLKTLI QAGIWKNTIP KQGARTKDGG PTAGRKTEAR PELTTSQDTK LGLQPVVSLD AEFLRQQRRF SSPRVLLSEN TPLEPPPLYV MEEPLALNRT SRRKRYTEGK THRGEYSVCD SESRWVTDKT SAVDIRGHQV TVLGEIRMGP SPVKQYFXET RCKQAKPAKS GCRGIDDKHW NSQCKTSQTF VRA //