ID A0A1Y1BWD5_9SAUR Unreviewed; 213 AA. AC A0A1Y1BWD5; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 27-NOV-2024, entry version 23. DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037}; DE Short=NT-3 {ECO:0000256|RuleBase:RU365037}; DE Flags: Fragment; GN Name=NT3 {ECO:0000313|EMBL:BAX64230.1}; OS Sinomicrurus iwasakii. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; OC Serpentes; Colubroidea; Elapidae; Elapinae; Sinomicrurus. OX NCBI_TaxID=34994 {ECO:0000313|EMBL:BAX64230.1}; RN [1] {ECO:0000313|EMBL:BAX64230.1} RP NUCLEOTIDE SEQUENCE. RA Kaito T., Ota H., Toda M.; RT "The evolutionary history and taxonomic reevaluation of the Japanese coral RT snake, Sinomicrurus japonicus (Serpentes, Elapidae), endemic to the Ryukyu RT Archipelago, Japan, by use of molecular and morphological analyses."; RL J. Zool. Syst. Evol. Res. 55:156-166(2017). CC -!- FUNCTION: Nerve growth factor is important for the development and CC maintenance of the sympathetic and sensory nervous systems. It CC stimulates division and differentiation of sympathetic and embryonic CC sensory neurons as well as basal forebrain cholinergic neurons in the CC brain. Its relevance in the snake venom is not clear. However, it has CC been shown to inhibit metalloproteinase-dependent proteolysis of CC platelet glycoprotein Ib alpha, suggesting a metalloproteinase CC inhibition to prevent metalloprotease autodigestion and/or protection CC against prey proteases. Binds a lipid between the two protein chains in CC the homodimer. The lipid-bound form promotes histamine relase from CC mouse mast cells, contrary to the lipid-free form. CC {ECO:0000256|ARBA:ARBA00045475}. CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312, CC ECO:0000256|RuleBase:RU365037}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU365037}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC094132; BAX64230.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1Y1BWD5; -. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR InterPro; IPR045815; NTF3_N. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1. DR Pfam; PF00243; NGF; 1. DR Pfam; PF19338; NTF3_N; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685, KW ECO:0000256|RuleBase:RU365037}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030, KW ECO:0000256|RuleBase:RU365037}; KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU365037}; KW Signal {ECO:0000256|ARBA:ARBA00022729}. FT DOMAIN 131..213 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT REGION 37..67 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAX64230.1" FT NON_TER 213 FT /evidence="ECO:0000313|EMBL:BAX64230.1" SQ SEQUENCE 213 AA; 23924 MW; 9F9FBA2A00E63843 CRC64; LAFLSGIQST SMDQRSLSED SMNSFLKTLI QAGIWKNTTP KQGARTKDGV PTAGRKTEAG PELTTSQDTK LGLQPVVSLD AEFLRQQRRF SSPRVLLSEN TPLEPPPLYL MEEPLALNRT SRRKRYTEGK THRGEYSVCD SESRWVTDKT SAVDIRGHQV TVLGEIRMGP SPVKQYFYET RCKQAKPAKS GCRGIDDKHW NSQCKTSQTF VRA //