ID A0A1X9YLN0_HPV05 Unreviewed; 57 AA. AC A0A1X9YLN0; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 22-FEB-2023, entry version 16. DE RecName: Full=Major capsid protein L1 {ECO:0000256|RuleBase:RU361248}; DE Flags: Fragment; GN Name=L1 {ECO:0000256|RuleBase:RU361248}; OS Human papillomavirus 5. OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; OC Betapapillomavirus. OX NCBI_TaxID=333923 {ECO:0000313|EMBL:ARS33714.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ARS33714.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HPV/EGY/2015/EI-4 {ECO:0000313|EMBL:ARS33714.1}; RX PubMed=28854484; RA Hamza H., Hamza I.A.; RT "Oncogenic papillomavirus and polyomavirus in urban sewage in Egypt."; RL Sci. Total Environ. 610-611:1413-1420(2017). CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm CC diameter. The capsid is composed of 72 pentamers linked to each other CC by disulfide bonds and associated with L2 proteins. Binds to heparan CC sulfate proteoglycans on cell surface of basal layer keratinocytes to CC provide initial virion attachment. This binding mediates a CC conformational change in the virus capsid that facilitates efficient CC infection. The virion enters the host cell via endocytosis. During CC virus trafficking, L1 protein dissociates from the viral DNA and the CC genomic DNA is released to the host nucleus. The virion assembly takes CC place within the cell nucleus. Encapsulates the genomic DNA together CC with protein L2. {ECO:0000256|RuleBase:RU361248}. CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an CC icosahedral symmetry and consists of 72 capsomers, with each capsomer CC being a pentamer of L1. Interacts with the minor capsid protein L2; CC this interaction is necessary for viral genome encapsidation. CC {ECO:0000256|RuleBase:RU361248}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328, CC ECO:0000256|RuleBase:RU361248}. CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family. CC {ECO:0000256|RuleBase:RU361248}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY848453; ARS33714.1; -; Genomic_DNA. DR GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR Gene3D; 2.60.175.20; Major capsid L1 (late) superfamily, Papillomavirus; 1. DR InterPro; IPR002210; Capsid_L1_Papillomavir. DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir. DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid. DR Pfam; PF00500; Late_protein_L1; 1. DR SUPFAM; SSF88648; Group I dsDNA viruses; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|RuleBase:RU361248}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581, KW ECO:0000256|RuleBase:RU361248}; KW Late protein {ECO:0000256|ARBA:ARBA00022921, KW ECO:0000256|RuleBase:RU361248}; KW T=7 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022828, KW ECO:0000256|RuleBase:RU361248}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU361248}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595}; KW Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|RuleBase:RU361248}; KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU361248}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ARS33714.1" FT NON_TER 57 FT /evidence="ECO:0000313|EMBL:ARS33714.1" SQ SEQUENCE 57 AA; 6358 MW; 2DC72E01195CE77F CRC64; NRFALADMSV YNPDKERLVW ACRGLEIGRG QPLGVGSTGH PYFNKVKDTE NSNAYIT //