ID A0A1X9YLL5_9PAPI Unreviewed; 107 AA. AC A0A1X9YLL5; DT 30-AUG-2017, integrated into UniProtKB/TrEMBL. DT 30-AUG-2017, sequence version 1. DT 02-JUN-2021, entry version 10. DE RecName: Full=Major capsid protein L1 {ECO:0000256|RuleBase:RU361248}; DE Flags: Fragment; GN Name=L1 {ECO:0000256|RuleBase:RU361248}; OS Human papillomavirus type 6. OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; OC Alphapapillomavirus. OX NCBI_TaxID=31552 {ECO:0000313|EMBL:ARS33698.1}; RN [1] {ECO:0000313|EMBL:ARS33698.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HPV/EGY/2015/ZI-11 {ECO:0000313|EMBL:ARS33698.1}; RX PubMed=28854484; RA Hamza H., Hamza I.A.; RT "Oncogenic papillomavirus and polyomavirus in urban sewage in Egypt."; RL Sci. Total Environ. 610-611:1413-1420(2017). CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm CC diameter. The capsid is composed of 72 pentamers linked to each other CC by disulfide bonds and associated with L2 proteins. Binds to heparan CC sulfate proteoglycans on cell surface of basal layer keratinocytes to CC provide initial virion attachment. This binding mediates a CC conformational change in the virus capsid that facilitates efficient CC infection. The virion enters the host cell via endocytosis. During CC virus trafficking, L1 protein dissociates from the viral DNA and the CC genomic DNA is released to the host nucleus. The virion assembly takes CC place within the cell nucleus. Encapsulates the genomic DNA together CC with protein L2. {ECO:0000256|RuleBase:RU361248}. CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an CC icosahedral symmetry and consists of 72 capsomers, with each capsomer CC being a pentamer of L1. Interacts with the minor capsid protein L2; CC this interaction is necessary for viral genome encapsidation. CC {ECO:0000256|RuleBase:RU361248}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328, CC ECO:0000256|RuleBase:RU361248}. CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family. CC {ECO:0000256|RuleBase:RU361248}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY848437; ARS33698.1; -; Genomic_DNA. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW. DR GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule. DR Gene3D; 2.60.175.20; -; 1. DR InterPro; IPR002210; Capsid_L1_Papillomavir. DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir. DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid. DR Pfam; PF00500; Late_protein_L1; 1. DR SUPFAM; SSF88648; SSF88648; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|RuleBase:RU361248}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581, KW ECO:0000256|RuleBase:RU361248}; KW Late protein {ECO:0000256|ARBA:ARBA00022921, KW ECO:0000256|RuleBase:RU361248}; KW T=7 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022828, KW ECO:0000256|RuleBase:RU361248}; KW Viral attachment to host cell {ECO:0000256|RuleBase:RU361248}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595}; KW Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|RuleBase:RU361248}; KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890}; KW Virus entry into host cell {ECO:0000256|RuleBase:RU361248}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ARS33698.1" FT NON_TER 107 FT /evidence="ECO:0000313|EMBL:ARS33698.1" SQ SEQUENCE 107 AA; 12302 MW; 8BFA5538B5220744 CRC64; RSTNMTLCAS VTTSSTYTNS DYKEYMRHVE EYDLQFIFQL CSITLSAEVM AYIHTMNPSV LEDWNFGLSP PPNGTLEDTY RYVQSQAITC QKPTPEKQKP DPYKNLS //