ID   A0A1X3LDT7_ECOLX        Unreviewed;       275 AA.
AC   A0A1X3LDT7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=2,5-diketo-D-gluconic acid reductase A (2,5-DKGreductase A) (2,5-DKGR A) (25DKGR-A) (AKR5C) {ECO:0000313|EMBL:OSL69243.1};
GN   ORFNames=EAXG_03902 {ECO:0000313|EMBL:OSL69243.1};
OS   Escherichia coli TA054.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=656433 {ECO:0000313|EMBL:OSL69243.1, ECO:0000313|Proteomes:UP000193131};
RN   [1] {ECO:0000313|EMBL:OSL69243.1, ECO:0000313|Proteomes:UP000193131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TA054 {ECO:0000313|EMBL:OSL69243.1,
RC   ECO:0000313|Proteomes:UP000193131};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S.,
RA   Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D.I.,
RA   Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T., Park D.,
RA   Pearson M., Richards J., Roberts A., Saif S., Shea T.D., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA   Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Escherichia coli TA054.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OSL69243.1}.
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DR   EMBL; ADKB01000012; OSL69243.1; -; Genomic_DNA.
DR   RefSeq; WP_000013149.1; NZ_ADKB01000012.1.
DR   SMR; A0A1X3LDT7; -.
DR   Proteomes; UP000193131; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; PTHR11732; 1.
DR   Pfam; PF00248; Aldo_ket_red; 2.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000193131}.
FT   DOMAIN       18    192       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   DOMAIN      201    261       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     51     51       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     107    107       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         76     76       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   275 AA;  31110 MW;  0FF6E140411BAD43 CRC64;
     MANPTVIKLQ DGNVMPQLGL GVWQASNEEV ITAIQKALEV GYRSIDTAAA YKNEEGVGKA
     LKNASVNREE LFITTKLWND DHKRPREALL DSLKKLQLDY IDLYLMHWPV PAIDHYVEAW
     KGMIELQKEG LIKSIGVCNF QIHHLQRLID ETGVTPVINQ IELHPLMQQR QLHAWNATHK
     IQTESWSPLA QGGKGVFDQK VIRDLADKYG KTPAQIVIRW HLDSGLVVIP KSVTPSRIAE
     NFDVWDFRLD KDELGEIAKL DQGKRLGPDP DQFGG
//