ID A0A1X3JE86_ECOLX Unreviewed; 441 AA. AC A0A1X3JE86; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 27-MAR-2024, entry version 17. DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:OSL05314.1}; GN ORFNames=ECVG_01360 {ECO:0000313|EMBL:OSL05314.1}; OS Escherichia coli H386. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=656397 {ECO:0000313|EMBL:OSL05314.1, ECO:0000313|Proteomes:UP000193045}; RN [1] {ECO:0000313|EMBL:OSL05314.1, ECO:0000313|Proteomes:UP000193045} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=H386 {ECO:0000313|EMBL:OSL05314.1, RC ECO:0000313|Proteomes:UP000193045}; RG The Broad Institute Genome Sequencing Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Feldgarden M., Gordon D.M., Johnson J.R., Johnston B.D., Young S., Zeng Q., RA Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D., RA Larson L., Mehta T., Park D., Pearson M., Richards J., Roberts A., Saif S., RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.; RT "The Genome Sequence of Escherichia coli H386."; RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SIMILARITY: Belongs to the peptidase M24B family. CC {ECO:0000256|ARBA:ARBA00008766}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OSL05314.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ADJB01000073; OSL05314.1; -; Genomic_DNA. DR RefSeq; WP_001290136.1; NZ_ADJB01000073.1. DR AlphaFoldDB; A0A1X3JE86; -. DR SMR; A0A1X3JE86; -. DR Proteomes; UP000193045; Unassembled WGS sequence. DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro. DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR CDD; cd01087; Prolidase; 1. DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1. DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1. DR InterPro; IPR007865; Aminopep_P_N. DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD. DR InterPro; IPR036005; Creatinase/aminopeptidase-like. DR InterPro; IPR000994; Pept_M24. DR InterPro; IPR001714; Pept_M24_MAP. DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS. DR PANTHER; PTHR43226:SF9; XAA-PRO AMINOPEPTIDASE; 1. DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1. DR Pfam; PF05195; AMP_N; 1. DR Pfam; PF00557; Peptidase_M24; 1. DR PRINTS; PR00599; MAPEPTIDASE. DR SMART; SM01011; AMP_N; 1. DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1. DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1. DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1. PE 3: Inferred from homology; KW Aminopeptidase {ECO:0000313|EMBL:OSL05314.1}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049}; KW Protease {ECO:0000256|ARBA:ARBA00022670}. FT DOMAIN 4..139 FT /note="Aminopeptidase P N-terminal" FT /evidence="ECO:0000259|SMART:SM01011" SQ SEQUENCE 441 AA; 49815 MW; 80A6A5BDD86D84B1 CRC64; MSEISRQEFQ RRRQALVEQM QPGSAALIFA APEVTRSADS EYPYRQNSDF WYFTGFNEPE AVLVLIKSDD THNHSVLFNR VRDLTAEIWF GRRLGQDAAP EKLGVDRALA FSEINQQLYQ LLNGLDVVYH AQGEYAYADV IVNSALEKLR KGSRQNLTAP ATMIDWRPVV HEMRLFKSPE EIAVLRRAGE ITAMAHTRAM EKCRPGMFEY HLEGEIHHEF NRHGARYPSY NTIVGSGENG CILHYTENEC EMRDGDLVLI DAGCEYKGYA GDITRTFPVN GKFTQAQREI YDIVLESLET SLRLYRPGTS ILEVTGEVVR IMVSGLVKLG ILKGDVDELI AQNAHRPFFM HGLSHWLGLD VHDVGVYGQD RSRILEPGMV LTVEPGLYIA PDAEVPEQYR GIGIRIEDDI VITETGNENL TASVVKKPEE IEALMVAARK Q //