ID A0A1X0PA66_9TRYP Unreviewed; 884 AA. AC A0A1X0PA66; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 02-DEC-2020, entry version 12. DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025}; DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025}; GN ORFNames=TM35_000016930 {ECO:0000313|EMBL:ORC93816.1}; OS Trypanosoma theileri. OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Trypanosoma. OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC93816.1, ECO:0000313|Proteomes:UP000192257}; RN [1] {ECO:0000313|EMBL:ORC93816.1, ECO:0000313|Proteomes:UP000192257} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC93816.1}; RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P., RA Matthews J., Matthews K., Carrington M.; RT "An alternative strategy for trypanosome survival in the mammalian RT bloodstream revealed through genome and transcriptome analysis of the RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- CC residue protein attached to proteins as an intracellular targeting CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025}; CC -!- SIMILARITY: Belongs to the peptidase C19 family. CC {ECO:0000256|RuleBase:RU366025}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ORC93816.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBCO01000001; ORC93816.1; -; Genomic_DNA. DR OrthoDB; 77113at2759; -. DR Proteomes; UP000192257; Unassembled WGS sequence. DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW. DR GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IEA:UniProtKB-EC. DR GO; GO:0016579; P:protein deubiquitination; IEA:UniProtKB-UniRule. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR InterPro; IPR001394; Peptidase_C19_UCH. DR InterPro; IPR018200; USP_CS. DR InterPro; IPR028889; USP_dom. DR Pfam; PF00443; UCH; 1. DR SUPFAM; SSF54001; SSF54001; 1. DR PROSITE; PS00972; USP_1; 1. DR PROSITE; PS00973; USP_2; 1. DR PROSITE; PS50235; USP_3; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|RuleBase:RU366025, ECO:0000313|EMBL:ORC93816.1}; KW Protease {ECO:0000256|RuleBase:RU366025}; KW Reference proteome {ECO:0000313|Proteomes:UP000192257}; KW Thiol protease {ECO:0000256|RuleBase:RU366025}; KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}. FT DOMAIN 20..332 FT /note="USP" FT /evidence="ECO:0000259|PROSITE:PS50235" SQ SEQUENCE 884 AA; 101798 MW; 604F6824888CFD92 CRC64; MLRNTYCFSY EEREKPPPYS GLVNQGSTCY LNAVIQVLYH LPAFRYSIYS IEEPEKHSIT LALRNIFSQL NCSYSFISTK DLTDAFGWED KEAYIQQDVH EMMQKLFQIL ERVCKNTPQE NFIRDLFYGE ITYITRTVDG VDHTTYHKEG FYDIELSVKD KNSIYDSLDQ WIQPERMENV SLEIEKGKPS SVHVVERKQF FSRLPPVLLV HPNRVCFSTE TCEVLMLENK WTFSNSLNLE SYIFSEGGDN VKDVKNLGTK YELRSVIIHQ GGAHSGHYLS YVHIGEEWIC FNDNSVSRVN EKIVMQAAYG GKRGYLSGFS NERASLLMYV NKKKSDEILK EKPIPKHLKD VAENINELNK RKWDEAYTKK EYYYLKDGER LIHVLDGYAN RGLKSSLFSS LCTSSIQDLY NTIAAEINQT ADKFRIWVYP EIPIMKSGCG ILKDITSIKF FFFVESLPKP KEEIEALSKD YFFAPVRLVY EDTLRFYGIV HSREELKELM MENKEKMKCF MCTFPPTVYE VSVDEVLIGS NLILCPESVS NKSLLYILQR LLYNEVHLFL LENKNANSWK PFGSFQLDNN TSYEDLQKEA FRLLSLAGLH LPPSPEYIGF HSQISSDSAV PSLSIAPPIS DNGCTSTLGS ILAHQNEMGC LYVQILPLPL SLLDVLRVVI FNVGGGFRPL VFIEKKNYTL GELFRITLDQ YGSYLSPELV QRITRSLQEN IPALRLLSYE EMLHLNVQVN NEERIPLTPG YYIIDVLVEV KEGFSLIDVL FCSRRKKEDY FGFPTNIPIS NTYEETGEEI ARRVADKIKA TEEVADITLW IVAIREQKGF YHTIGSKDSL KSVIKRISSE VECFVIDRPR SFSLDGVENS HQKSEQSIVI RETS //