ID   A0A1X0NIN2_9TRYP        Unreviewed;       752 AA.
AC   A0A1X0NIN2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   17-JUN-2020, entry version 14.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   ORFNames=TM35_000431700 {ECO:0000313|EMBL:ORC84602.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC84602.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC84602.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC84602.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU004273};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC84602.1}.
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DR   EMBL; NBCO01000043; ORC84602.1; -; Genomic_DNA.
DR   OrthoDB; 228114at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU004273};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT   DOMAIN          433..438
FT                   /note="SER_THR_PHOSPHATASE"
FT                   /evidence="ECO:0000259|PROSITE:PS00125"
FT   REGION          148..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..539
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  84233 MW;  FBC6CC4D5E0F6206 CRC64;
     MWDKHCIVVE EGRELIVGTD PLCDVQVTLP KLRVFGSHLV VSRYHDIAHV ICSTNGVLLL
     SISTRSLSVY IHGIQVVPSR EPIELYPGSP VSFGGRHKGT TFCFFTSHTS PAVISPMPSA
     KFSPLALNLN GMKKSLPFPP LNATCNVTEQ GVSPRSPRVV RIIGPSDNDN DNDNDDNDNN
     GNSNKYMSTC HTSVSLLSSF KNSSKSISNY GKSITTYDTQ WKFNTENKLP SSHTIVPFVV
     ELWGLRATLH SVIGHNTQSR SASTRSCGVA EISGRGGNTP GDPYFTFRGC EMLKGLHLSR
     IETPVRSAAA SVLESLEDAY EPGEGTFLQF TTSAKNSLFQ HFLLLADHAL IELQKTPLTV
     RRCSPIVCCG DIHGSFSDLK TIFDNVVPFH HWSLMTMPVL FLGDYVDRGP HDVEVVLFLL
     AWYILCPENV ILLRGNHEDE EVNGDIQLYG ETSFRKKCWK FFNKDNGEIF WNRVNDVFAE
     LPIVAIIDST IFACHGGIPL LREKSSSETG EVKNGKKGFG VRQQQRKQEE NKKEEQDTDH
     VELMNDVPCM EFFQLLINGM PNELEEFRFR CMMPDVHDND LKAQHRRLIR ELLWNDPVPQ
     FSTSTYGNNG NGTADTEFTQ QDGFDVNGFR TNFGRGDHRN VIREFSASAL VSFMERWGFT
     LLIRAHQQKM AGIEMGLAGR ILTLFSCCNY TGDTNRAGAC IVVDGEVRLV SWRTVLGTSR
     DEPPPETLRS SFDDSEETQI PHYVGLRRLR FG
//