ID   A0A1W6JSC0_9CAUD        Unreviewed;       608 AA.
AC   A0A1W6JSC0;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   14-DEC-2022, entry version 22.
DE   RecName: Full=DNA polymerase {ECO:0000256|ARBA:ARBA00015749, ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU000442};
GN   ORFNames=HARAMBE_5 {ECO:0000313|EMBL:ARM70154.1};
OS   Bacillus phage Harambe.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Salasmaviridae; Harambevirus; Harambevirus harambe.
OX   NCBI_TaxID=1981931 {ECO:0000313|EMBL:ARM70154.1, ECO:0000313|Proteomes:UP000221132};
RN   [1] {ECO:0000313|Proteomes:UP000221132}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Abille Z., Afsharjavan R., Alms C.E., Anil A., Azuma E.A., Boateng D.,
RA   Bowden K.V., Bui Q., Callaghan K.D., Canova P.N., Carter A.-G.V., Carty B.,
RA   Choudhary A., Chugh K., Clark C.B., Clark J., Cortez R., Dalwadi R.M.,
RA   Daou G., Das M., Dasari S., Davis E.H., Defreitas N., Demirji J.,
RA   Endres C., Fakhar S., Feeley N., Flores D.C., Fowler A.R., George T.,
RA   Greis H.L., Groleau D.L., Gulati J.K., Guzman W., Hallworth A.N.,
RA   Hariri A., Haya V.N., Hoffman A.K., Horne B., Howard T., Iglesia A.J.,
RA   Ijezie O.D., Incognito N.A., Inen J.A., Jaiswal A., Jezek R.A., Kawa A.C.,
RA   Khan F., Khin A.C., Knapo J., Kong A.S., Le B.Q., Le Q.M., Le T.-H.M.,
RA   Lee M., Lockwood J.L., Loto-Rojas G.S., Mantzavinos A., Martinez D.R.,
RA   Meadows A.R., Mehr S., Mellon M.N., Memon S., Miller B., Min S.,
RA   Mitchell L.M., Mohamed I.R., Mohammed F.O., More S., Muntaha S., Nadeem I.,
RA   Ndjeumen-Njinguet A.S., Ng P., Ngu V.E., Nguyen B.N., OHern C.T.,
RA   Oboh U.S., Pagano C.W., Panakal P.R., Park D.A., Parsana D., Patel P.,
RA   Patel V.S., Patwardhan V.M., Pawar S.D., Payne V.R., Petricel I.M.,
RA   Phillips C., Puglisi K.M., Ramaprasad G., Raza A.S., Rivera-Oven A.G.,
RA   Robins E., Roeun D.C., Rostovtseva N., Sadat M., Seas A., So E.J.,
RA   Sogbesan C., Strumsky L.A., Sun J.L., Sutherland H.J., Tchakounte I.,
RA   Tewell J.R., Thapa D.J., Tkach Y., Tran C.D., Tran V., Vithayathil T.,
RA   Vivekanandan A., Wang S.R., White E., Yang A.L., Ye D.T., Yirenkyi M.,
RA   Zarb J.S., Zhang S., Zhou M.T., Cao A., Nguyen K.M., Patel K., Patel P.,
RA   Pennington E., Sendze O., Zahangir S., Correa-Mendez M., Fabian M.F.,
RA   Liu S., Jethmalani Y., Nunn R., Prakash A., Louise T., Johnson A.,
RA   Erill I., Caruso S.M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KY821088; ARM70154.1; -; Genomic_DNA.
DR   SMR; A0A1W6JSC0; -.
DR   Proteomes; UP000221132; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0001882; F:nucleoside binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR014416; DNA-dir_DNA_polB_phi29_vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   PIRSF; PIRSF004178; Dpol_Bac_phage; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221132};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW   Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT   DOMAIN          98..483
FT                   /note="DNA_pol_B_2"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
SQ   SEQUENCE   608 AA;  70668 MW;  8DCE9E42F016DB9D CRC64;
     MGNKKRKIYS CDFETTTDVN DCRVWAYGLM EIDGKFENYK EGNNIDEFME WTEQEQGDLY
     FHNLRFDGEF IVNWLLHKGY RFNNTRKAGT FNAVISSMGQ WYKIDIYYGR EGKKVFKTSI
     YDSLKKLPFP VKTIAKAFKL PIEKGDIDYD APRPVGHQIT PDESKYIKND VEIIARALHS
     QLNTAKLTKM TIGSDALDGF KHSLHKSPKV SKRMYDHHFP VISNAIHEEF KKAYRGGFTW
     ANPKYAGKVI GNGLVFDVNS LYPSVMYDKP LPYGLPVPFS GEYEYDETHP LFIQHIKCGF
     ELKDGHIPTI QIKKNFRFAD NEYLHSSEGN ILDLHVTNVD LALIKEHYTL YEEEYLQGYK
     FKQVTGLFKN YIDYWSDKKI NAEDPAIRQM AKLMLNSLYG KFGTSIDVTG KEVFLKEDGS
     TGFRKGQKEE RDPVYMPMGA FITAYARDVT IRTAQKCYDR ILYCDTDSIH LVGTEIPEAI
     KDRIHDKKLG YWAHESTFWR AKFIRQKTYI EDLCMRFEGE KVNGEWKFKM VEEKDITKAT
     ARELSVKCAG MPAQVKQYVT FDNFGVDFKH DPNDYTDEEI KRKNIKFKLK PTHRKGGQVL
     VPTPFTIK
//