ID A0A1W6JRV2_9CAUD Unreviewed; 71 AA. AC A0A1W6JRV2; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 05-JUN-2019, entry version 7. DE RecName: Full=Holin {ECO:0000256|HAMAP-Rule:MF_04108}; GN ORFNames=WRT_044 {ECO:0000313|EMBL:ARM69608.1}; OS Pseudomonas virus WRT. OC Viruses; Caudovirales; Podoviridae; Autographivirinae; Teseptimavirus. OX NCBI_TaxID=1981932 {ECO:0000313|EMBL:ARM69608.1, ECO:0000313|Proteomes:UP000222154}; RN [1] {ECO:0000313|EMBL:ARM69608.1, ECO:0000313|Proteomes:UP000222154} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WRT {ECO:0000313|EMBL:ARM69608.1, RC ECO:0000313|Proteomes:UP000222154}; RA Barylski J., Nowicki G., Walkowiak-Nowicka K.; RT "Complete genome sequence of two novel autographiviruses infecting RT bacterium from Pseudomonas fluorescens group."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Accumulates harmlessly in the cytoplasmic membrane until CC it reaches a critical concentration that triggers the formation of CC micron-scale pores (holes) causing host cell membrane disruption CC and endolysin escape into the periplasmic space. Participates in CC determining the precise timing of host cell lysis. Participates CC with the endolysin and spanin proteins in the sequential events CC which lead to the programmed host cell lysis releasing the mature CC viral particles from the host cell. {ECO:0000256|HAMAP- CC Rule:MF_04108}. CC -!- SUBUNIT: Homomultimer. {ECO:0000256|HAMAP-Rule:MF_04108}. CC -!- SUBCELLULAR LOCATION: Host cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_04108}; Single-pass type II membrane protein CC {ECO:0000256|HAMAP-Rule:MF_04108}; Periplasmic side CC {ECO:0000256|HAMAP-Rule:MF_04108}. Note=Classified as a class II CC holin although it seems to have only one transmembrane domain. CC {ECO:0000256|HAMAP-Rule:MF_04108}. CC -!- SIMILARITY: Belongs to the T7likevirus holin family. CC {ECO:0000256|HAMAP-Rule:MF_04108}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY798120; ARM69608.1; -; Genomic_DNA. DR Proteomes; UP000222154; Genome. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0034291; F:canonical holin activity; IEA:UniProtKB-UniRule. DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule. DR HAMAP; MF_04108; HOLIN_T7; 1. DR InterPro; IPR019682; Phage_T7_Gp17.5_holin. DR Pfam; PF10746; Phage_holin_2_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000222154}; KW Cytolysis {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell inner membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell lysis by virus {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_04108, ECO:0000256|SAM:Phobius}; KW Signal-anchor {ECO:0000256|HAMAP-Rule:MF_04108}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_04108, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04108, KW ECO:0000256|SAM:Phobius}; KW Viral release from host cell {ECO:0000256|HAMAP-Rule:MF_04108}. FT TOPO_DOM 1 37 Cytoplasmic. {ECO:0000256|HAMAP-Rule: FT MF_04108}. FT TRANSMEM 38 56 Helical. {ECO:0000256|SAM:Phobius}. FT TOPO_DOM 57 71 Periplasmic. {ECO:0000256|HAMAP-Rule: FT MF_04108}. SQ SEQUENCE 71 AA; 7593 MW; 4748E9FB5B5EDB0A CRC64; MAGLEIDFTN GVVRAAPIAA GAGAEVASQV AGMSLSDWFY ATIILYTIVQ TFVLVFKTVM DEKRKNKGDP P //