ID A0A1W6JRV2_9CAUD Unreviewed; 71 AA. AC A0A1W6JRV2; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 24-JUL-2024, entry version 18. DE RecName: Full=Holin {ECO:0000256|HAMAP-Rule:MF_04108}; GN ORFNames=WRT_044 {ECO:0000313|EMBL:ARM69608.1}; OS Pseudomonas phage WRT. OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; OC Autographiviridae; Studiervirinae; Ghunavirus; Ghunavirus WRT. OX NCBI_TaxID=2783803 {ECO:0000313|EMBL:ARM69608.1, ECO:0000313|Proteomes:UP000222154}; RN [1] {ECO:0000313|EMBL:ARM69608.1, ECO:0000313|Proteomes:UP000222154} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WRT {ECO:0000313|EMBL:ARM69608.1, RC ECO:0000313|Proteomes:UP000222154}; RA Barylski J., Nowicki G., Walkowiak-Nowicka K.; RT "Complete genome sequence of two novel autographiviruses infecting RT bacterium from Pseudomonas fluorescens group."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Accumulates harmlessly in the cytoplasmic membrane until it CC reaches a critical concentration that triggers the formation of micron- CC scale pores (holes) causing host cell membrane disruption and endolysin CC escape into the periplasmic space. Participates in determining the CC precise timing of host cell lysis. Participates with the endolysin and CC spanin proteins in the sequential events which lead to the programmed CC host cell lysis releasing the mature viral particles from the host CC cell. {ECO:0000256|HAMAP-Rule:MF_04108}. CC -!- SUBUNIT: Homomultimer. {ECO:0000256|HAMAP-Rule:MF_04108}. CC -!- SUBCELLULAR LOCATION: Host cell inner membrane {ECO:0000256|HAMAP- CC Rule:MF_04108}; Single-pass type II membrane protein CC {ECO:0000256|HAMAP-Rule:MF_04108}; Periplasmic side {ECO:0000256|HAMAP- CC Rule:MF_04108}. Note=Classified as a class II holin although it seems CC to have only one transmembrane domain. {ECO:0000256|HAMAP- CC Rule:MF_04108}. CC -!- SIMILARITY: Belongs to the T7likevirus holin family. CC {ECO:0000256|HAMAP-Rule:MF_04108}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY798120; ARM69608.1; -; Genomic_DNA. DR Proteomes; UP000222154; Segment. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0140911; F:pore-forming activity; IEA:UniProtKB-UniRule. DR GO; GO:0044659; P:viral release from host cell by cytolysis; IEA:InterPro. DR HAMAP; MF_04108; HOLIN_T7; 1. DR InterPro; IPR019682; Phage_T7_Gp17.5_holin. DR Pfam; PF10746; Phage_holin_2_2; 1. PE 3: Inferred from homology; KW Cytolysis {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell inner membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell lysis by virus {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Host membrane {ECO:0000256|HAMAP-Rule:MF_04108}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_04108, ECO:0000256|SAM:Phobius}; KW Signal-anchor {ECO:0000256|HAMAP-Rule:MF_04108}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_04108, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04108, KW ECO:0000256|SAM:Phobius}; KW Viral release from host cell {ECO:0000256|HAMAP-Rule:MF_04108}. FT TOPO_DOM 1..37 FT /note="Cytoplasmic" FT /evidence="ECO:0000256|HAMAP-Rule:MF_04108" FT TRANSMEM 38..56 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TOPO_DOM 57..71 FT /note="Periplasmic" FT /evidence="ECO:0000256|HAMAP-Rule:MF_04108" SQ SEQUENCE 71 AA; 7593 MW; 4748E9FB5B5EDB0A CRC64; MAGLEIDFTN GVVRAAPIAA GAGAEVASQV AGMSLSDWFY ATIILYTIVQ TFVLVFKTVM DEKRKNKGDP P //