ID A0A1W6GAI0_9BETA Unreviewed; 1012 AA. AC A0A1W6GAI0; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 05-DEC-2018, entry version 9. DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442}; DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442}; OS Human betaherpesvirus 6. OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Roseolovirus; unclassified Roseolovirus. OX NCBI_TaxID=10368 {ECO:0000313|EMBL:ARM09815.1}; RN [1] {ECO:0000313|EMBL:ARM09815.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HP23A7 {ECO:0000313|EMBL:ARM07012.1}, HP73F12 RC {ECO:0000313|EMBL:ARM08003.1}, HP94B11 {ECO:0000313|EMBL:ARM09097.1}, RC and JHPT-D12 {ECO:0000313|EMBL:ARM09815.1}; RA Greninger A.L., Hall Sedlak R., Roychoudhury P., Xie H., Guan J., RA Peddu V., Huang M.-L., Cook L., Yoshikawa T., Caserta M., Hill J.A., RA Jerome K.R.; RT "A rash of human herpesvirus 6 genomes."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:61560, ChEBI:CHEBI:83828, Rhea:RHEA-COMP:11130, CC Rhea:RHEA-COMP:11131; EC=2.7.7.7; CC Evidence={ECO:0000256|RuleBase:RU000442}; CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. CC {ECO:0000256|RuleBase:RU000442}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY315531; ARM07012.1; -; Genomic_DNA. DR EMBL; KY315540; ARM08003.1; -; Genomic_DNA. DR EMBL; KY315549; ARM09097.1; -; Genomic_DNA. DR EMBL; KY315555; ARM09815.1; -; Genomic_DNA. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR Gene3D; 3.30.420.10; -; 1. DR Gene3D; 3.90.1600.10; -; 1. DR InterPro; IPR006172; DNA-dir_DNA_pol_B. DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS. DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc. DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom. DR InterPro; IPR023211; DNA_pol_palm_dom_sf. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR Pfam; PF00136; DNA_pol_B; 1. DR Pfam; PF03104; DNA_pol_B_exo1; 1. DR PRINTS; PR00106; DNAPOLB. DR SMART; SM00486; POLBc; 1. DR SUPFAM; SSF53098; SSF53098; 1. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. PE 3: Inferred from homology; KW DNA replication {ECO:0000256|RuleBase:RU000442}; KW DNA-binding {ECO:0000256|RuleBase:RU000442}; KW DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442}; KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442, KW ECO:0000313|EMBL:ARM09815.1}; KW Transferase {ECO:0000256|RuleBase:RU000442, KW ECO:0000313|EMBL:ARM09815.1}. FT DOMAIN 123 444 DNA_pol_B_exo1. {ECO:0000259|Pfam: FT PF03104}. FT DOMAIN 509 979 DNA_pol_B. {ECO:0000259|Pfam:PF00136}. SQ SEQUENCE 1012 AA; 115803 MW; 08D0F4E21546D949 CRC64; MDSVSFFNPY LEANRLKKKS RSSYIRILPR GIMHDGAAGL IKDVCDSEPR MFYRDRQYLL SKEMTWPSLD IARSKDYDHM RMKFHIYDAV ETLMFTDSIE NLPFQYRHFV IPSGTVIRMF GRTEDGEKIC VNVFGQEQYF YCECVDGKSL KATINNLMLT GEVKMSCSFV IEPADKLSLY GYNANTVVNL FKVSFGNFYV SQRIGKILQN EGFVVYEIDV DVLTRFFVDN GFLSFGWYNV KKYIPQDMGK GSNLEVEINC HVSDLVSLED VNWPLYGCWS FDIECLGQNG NFPDAENLGD IVIQISVISF DTEGDRDERH LFTLGTCEKI DGVHIYEFAS EFELLLGFFI FLRIESPEFI TGYNINNFDL KYLCIRMDKI YHYDIGCFSK LKNGKIGISV PHEQYRKGFL QAQTKVFTSG VLYLDMYPVY SSKITAQNYK LDTIAKICLQ QEKEQLSYKE IPKKFISGPS GRAVVGKYCL QDSVLVVRLF KQINYHYEVV EVARLAHVTA RCVVFEGQQK KIFPCILTEA KRRNMILPSM VSSHNRQGIG YKGATVLEPK TGYYAVPTVV FDFQSLYPSI MMAHNLCYST LVLDERQIAG LSESDILTVK LGDETHRFVK PCIRESVLGS LLKDWLAKRR EVKAEMQNCS DPMMKLLLDK KQLALKTTCN SVYGVTGAAH GLLPCVAIAA SVTCLGREML CSTVDYVNSK MQSEQFFCEE FGLTSSDFTG DLKVEVIYGD TDSIFMSVRN MVNQSLRRIA PMIAKHITDR LFKSPIKLEF EKILCPLILI CKKRYIGRQD DSLLIFKGVD LVRKTSCDFV KGVVKDIVDL LFFDEEVQTA AVEFSHMTQT QLREQGVPVG IHKILRRLCE AREELFQNRA DVRHLMLSSV LSKEMAAYKQ PNLAHLSVIR RLAQRKEEIP NVGDRIMYVL IAPSIGNKQT HNYELAEDPN YVIEHKIPIH AEKYFDQIIK AVTNAISPIF PKTDIKKEKL LLYLLPVKVY LDETFSAIAE VM //