ID A0A1W5T4H0_MYCAM Unreviewed; 229 AA. AC A0A1W5T4H0; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 27-NOV-2024, entry version 19. DE SubName: Full=Nerve growth factor beta polypeptide {ECO:0000313|EMBL:ARF06651.1}; DE Flags: Fragment; GN Name=NGF {ECO:0000313|EMBL:ARF06651.1}; OS Mycteria americana (Wood stork). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Ciconiiformes; OC Ciconiidae; Mycteria. OX NCBI_TaxID=33587 {ECO:0000313|EMBL:ARF06651.1}; RN [1] {ECO:0000313|EMBL:ARF06651.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28369655; RA Reddy S., Kimball R.T., Pandey A., Hosner P.A., Braun M.J., Hackett S.J., RA Han K.L., Harshman J., Huddleston C.J., Kingston S., Marks B.D., RA Miglia K.J., Moore W.S., Sheldon F.H., Witt C.C., Yuri T., Braun E.L.; RT "Why Do Phylogenomic Data Sets Yield Conflicting Trees? Data Type RT Influences the Avian Tree of Life more than Taxon Sampling."; RL Syst. Biol. 66:857-879(2017). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY763528; ARF06651.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1W5T4H0; -. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:TreeGrafter. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR FunFam; 2.10.90.10:FF:000002; Brain-derived neurotrophic factor; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR020425; Nerve_growth_factor_bsu. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR00268; NGF. DR PRINTS; PR01913; NGFBETA. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001789-1}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}. FT DOMAIN 117..221 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT DISULFID 125..190 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 168..218 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT DISULFID 178..220 FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ARF06651.1" SQ SEQUENCE 229 AA; 25797 MW; 830EE863D43515E6 CRC64; AFLIGTQAAP KSEDNAPLEY PAEHSLLNTH RSNRHHIPKA AAQTFHGHHT WTMGRREAIN ITMDPKFFKN RRFRSPRVLF STQPPPASRQ GQNMGFLSSA VSLNRTARTK RTAHPVLHRG EFSVCDSVSM WVGDKTTATD IKGKEVTVLG EVNINNNVFK QYFFETKCRD PKPVSSGCRG IDAKHWNSYC TTTHTFVKAL TMEGKQAAWR FIRIDTACVC VLSRKSGRP //