ID A0A1W5G6R8_9PRIM Unreviewed; 459 AA. AC A0A1W5G6R8; DT 05-JUL-2017, integrated into UniProtKB/TrEMBL. DT 05-JUL-2017, sequence version 1. DT 30-AUG-2017, entry version 2. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003297}; GN Name=ND4 {ECO:0000313|EMBL:ADP68202.1}; OS Lepilemur betsileo. OG Mitochondrion {ECO:0000313|EMBL:ADP68202.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; OC Lemuriformes; Lepilemuridae; Lepilemur. OX NCBI_TaxID=886958 {ECO:0000313|EMBL:ADP68202.1}; RN [1] {ECO:0000313|EMBL:ADP68202.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=FAN6.1 {ECO:0000313|EMBL:ADP68202.1}; RX PubMed=28173059; DOI=.1093/jhered/esw072; RA Lei R., Frasier C.L., Hawkins M.T., Engberg S.E., Bailey C.A., RA Johnson S.E., McLain A.T., Groves C.P., Perry G.H., Nash S.D., RA Mittermeier R.A., Louis E.E.; RT "Phylogenomic Reconstruction of Sportive Lemurs (genus Lepilemur) RT Recovered from Mitogenomes with Inferences for Madagascar RT Biogeography."; RL J. Hered. 108:107-119(2017). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ171066; ADP68202.1; -; Genomic_DNA. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAAS:SAAS00707373, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:ADP68202.1}; KW NAD {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707374}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707388}; KW Transmembrane {ECO:0000256|SAAS:SAAS00707385, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00707361, KW ECO:0000256|SAM:Phobius}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00699082}. FT TRANSMEM 21 42 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 62 82 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 94 110 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 116 133 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 145 167 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 193 212 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 224 244 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 256 277 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 284 303 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 309 329 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 350 368 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 388 409 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 109 Oxidored_q5_N. {ECO:0000259|Pfam: FT PF01059}. FT DOMAIN 113 398 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. SQ SEQUENCE 459 AA; 51793 MW; 82D7A865C26FAF19 CRC64; MLKIIVPTAM LLPVIWYSTN PMTWMNITLH SLTISLMSLF LFSQADTNSN NFSPTFFSDP LSSPLLVLTM WLLPLTVVAS QYHLTKEPWE RKKHFLSTLI SLQLLLVMTF ATTELIMFYI LFESTLIPTL VIITRWGNQT ERLNAGLYFL FYTLTGSLPL LVALSYIQSS MGTLNLFMMT YWLQELPNSW SNYLLWTACI MAFMIKMPLY GLHMWLPKAH VEAPIAGSMI LAAILLKLGG YGMMRITMIL NPLTKSMAYP FLMLCLWGMI MTSLICLRQT DLKSLIAYSS VSHMALVIVA ILIQTPWSLM GATTLMIAHG LTSSVLFCLA NSNYERVHSR TMLLARGLQA LLPLMSTWWL LASLSNLALP PSINLIGELL VTMAAFSWSN TTIILTGLNM LVTATYSLYM LTTTQRGKSP YHMQNFSPSL TRENTLMSMH ILPLLLLTLN PKILMGPTY //