ID   A0A1W5G325_9PRIM        Unreviewed;       227 AA.
AC   A0A1W5G325;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   RecName: Full=Cytochrome c oxidase subunit 2 {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709560};
GN   Name=COX2 {ECO:0000313|EMBL:ADP68443.1};
OS   Lepilemur hollandorum.
OG   Mitochondrion {ECO:0000313|EMBL:ADP68443.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lemuriformes; Lepilemuridae; Lepilemur.
OX   NCBI_TaxID=886961 {ECO:0000313|EMBL:ADP68443.1};
RN   [1] {ECO:0000313|EMBL:ADP68443.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NARA8.5 {ECO:0000313|EMBL:ADP68443.1};
RX   PubMed=28173059; DOI=10.1093/jhered/esw072;
RA   Lei R., Frasier C.L., Hawkins M.T., Engberg S.E., Bailey C.A.,
RA   Johnson S.E., McLain A.T., Groves C.P., Perry G.H., Nash S.D.,
RA   Mittermeier R.A., Louis E.E.;
RT   "Phylogenomic Reconstruction of Sportive Lemurs (genus Lepilemur)
RT   Recovered from Mitogenomes with Inferences for Madagascar
RT   Biogeography.";
RL   J. Hered. 108:107-119(2017).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC       {ECO:0000256|RuleBase:RU000457}.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000457};
CC       Note=Binds a copper A center. {ECO:0000256|RuleBase:RU000457};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709542};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU000457,
CC       ECO:0000256|SAAS:SAAS00709542}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00709553}.
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DR   EMBL; HQ171085; ADP68443.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR   CDD; cd13912; CcO_II_C; 1.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR002429; CcO_II-like_C.
DR   InterPro; IPR034210; CcO_II_C.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   InterPro; IPR036257; Cyt_c_oxidase_su2_TM_sf.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|RuleBase:RU000457, ECO:0000256|SAAS:SAAS00477878};
KW   Electron transport {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS01155864};
KW   Membrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00883094, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00119299};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00709499, ECO:0000313|EMBL:ADP68443.1};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00709564};
KW   Respiratory chain {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS01154861};
KW   Transmembrane {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS00882981, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00883111,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000457,
KW   ECO:0000256|SAAS:SAAS01155879}.
FT   TRANSMEM     27     46       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     66     85       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     91       COX2_TM. {ECO:0000259|PROSITE:PS50999}.
FT   DOMAIN       92    225       COX2_CUA. {ECO:0000259|PROSITE:PS50857}.
SQ   SEQUENCE   227 AA;  25994 MW;  260627EBB0F79B06 CRC64;
     MACPVQLGFQ DATSPIMEEL LYFHDHTLMI VFLISSLVLY VISLMLTTKL THTNTVDAQG
     VEMVWTILPA VILILIALPS LRILYMMDEI TTPSLTLKTM GHQWYWSYEY TDYENLNFDS
     YMIPLSDLKP GELRLLEVDN RITLPTEMSI RMLISSEDVL HSWAVPSLGV KTDAIPGRLN
     QVTLMTSRPG IYYGQCSEIC GANHSFMPIV LELVPLKYFE EWLMIMF
//