ID A0A1W2KEI3_9TELE Unreviewed; 194 AA. AC A0A1W2KEI3; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 24-JAN-2024, entry version 30. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|ARBA:ARBA00015947, ECO:0000256|RuleBase:RU000369}; DE EC=7.1.1.9 {ECO:0000256|ARBA:ARBA00012949, ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:ANP23606.1}; OS Sillago asiatica (Asian whiting). OG Mitochondrion {ECO:0000313|EMBL:ANP23606.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Sillaginidae; Sillago. OX NCBI_TaxID=1055099 {ECO:0000313|EMBL:ANP23606.1}; RN [1] {ECO:0000313|EMBL:ANP23606.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DYBYZ2 {ECO:0000313|EMBL:ANP23601.1}, DYBYZ4 RC {ECO:0000313|EMBL:ANP23602.1}, DYCYZ1 {ECO:0000313|EMBL:ANP23603.1}, RC DYCYZ3 {ECO:0000313|EMBL:ANP23604.1}, DYCYZ5 RC {ECO:0000313|EMBL:ANP23605.1}, PJYZ14 {ECO:0000313|EMBL:ANP23615.1}, RC PJYZ17 {ECO:0000313|EMBL:ANP23616.1}, PJYZ22 RC {ECO:0000313|EMBL:ANP23617.1}, PJYZ5 {ECO:0000313|EMBL:ANP23613.1}, RC PJYZ8 {ECO:0000313|EMBL:ANP23614.1}, STYZ1 RC {ECO:0000313|EMBL:ANP23611.1}, SYYZ1 {ECO:0000313|EMBL:ANP23606.1}, RC SYYZ2 {ECO:0000313|EMBL:ANP23607.1}, SYYZ3 RC {ECO:0000313|EMBL:ANP23608.1}, SYYZ4 {ECO:0000313|EMBL:ANP23609.1}, RC and SYYZ5 {ECO:0000313|EMBL:ANP23610.1}; RA Xiao J., Song N., Han Z., Shao K.-T., McKay R.J., Gao T.; RT "Cryptic diversity in Sillaginidae (Perciforms) across the Indo-West RT Pacific revealed by DNA barcoding."; RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ANP23606.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=STYZ1 {ECO:0000313|EMBL:ANP23611.1}, SYYZ1 RC {ECO:0000313|EMBL:ANP23606.1}, and SYYZ4 RC {ECO:0000313|EMBL:ANP23609.1}; RA Xiao J.-G., Song N., Han Z.-Q., Gao T.-X.; RT "Description and DNA Barcoding of a New Sillago Species, Sillago shaoi RT (Perciformes: Sillaginidae), in the Taiwan Strait."; RL Zool. Stud. 55:47-47(2016). RN [3] {ECO:0000313|EMBL:AUW64531.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Z4 {ECO:0000313|EMBL:AUW64531.1}; RA Xiao J., Song N., Gao T.; RT "Molecular phylogeny of Sillaginidae (Perciforms): evidence for necessary RT taxonomic revision in the family and the identification of cryptic RT diversity across the Indo-West Pacific."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the CC mitochondrial electron transport chain which drives oxidative CC phosphorylation. The respiratory chain contains 3 multisubunit CC complexes succinate dehydrogenase (complex II, CII), ubiquinol- CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to CC transfer electrons derived from NADH and succinate to molecular oxygen, CC creating an electrochemical gradient over the inner membrane that CC drives transmembrane transport and the ATP synthase. Cytochrome c CC oxidase is the component of the respiratory chain that catalyzes the CC reduction of oxygen to water. Electrons originating from reduced CC cytochrome c in the intermembrane space (IMS) are transferred via the CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 CC to the active site in subunit 1, a binuclear center (BNC) formed by CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 CC water molecules using 4 electrons from cytochrome c in the IMS and 4 CC protons from the mitochondrial matrix. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)- CC [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436, CC Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, CC ChEBI:CHEBI:29034; EC=7.1.1.9; CC Evidence={ECO:0000256|ARBA:ARBA00029331}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11437; CC Evidence={ECO:0000256|ARBA:ARBA00029331}; CC -!- COFACTOR: CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; CC Evidence={ECO:0000256|ARBA:ARBA00001935}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|ARBA:ARBA00004673, ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|ARBA:ARBA00009578, ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU051907; ANP23601.1; -; Genomic_DNA. DR EMBL; KU051908; ANP23602.1; -; Genomic_DNA. DR EMBL; KU051909; ANP23603.1; -; Genomic_DNA. DR EMBL; KU051910; ANP23604.1; -; Genomic_DNA. DR EMBL; KU051911; ANP23605.1; -; Genomic_DNA. DR EMBL; KU051912; ANP23606.1; -; Genomic_DNA. DR EMBL; KU051913; ANP23607.1; -; Genomic_DNA. DR EMBL; KU051914; ANP23608.1; -; Genomic_DNA. DR EMBL; KU051915; ANP23609.1; -; Genomic_DNA. DR EMBL; KU051916; ANP23610.1; -; Genomic_DNA. DR EMBL; KU051917; ANP23611.1; -; Genomic_DNA. DR EMBL; KU051919; ANP23613.1; -; Genomic_DNA. DR EMBL; KU051920; ANP23614.1; -; Genomic_DNA. DR EMBL; KU051921; ANP23615.1; -; Genomic_DNA. DR EMBL; KU051922; ANP23616.1; -; Genomic_DNA. DR EMBL; KU051923; ANP23617.1; -; Genomic_DNA. DR EMBL; MF571926; AUW64531.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1W2KEI3; -. DR UniPathway; UPA00705; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; Cytochrome c oxidase-like, subunit I domain; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; CYTOCHROME C OXIDASE SUBUNIT 1; 1. DR PANTHER; PTHR10422:SF18; CYTOCHROME C OXIDASE SUBUNIT 1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; Cytochrome c oxidase subunit I-like; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000369}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, ECO:0000313|EMBL:ANP23606.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000369}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 34..59 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 80..104 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 124..147 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 159..186 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..194 FT /note="Cytochrome oxidase subunit I profile" FT /evidence="ECO:0000259|PROSITE:PS50855" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ANP23606.1" FT NON_TER 194 FT /evidence="ECO:0000313|EMBL:ANP23606.1" SQ SEQUENCE 194 AA; 20582 MW; DE436B04A5264C15 CRC64; WAGMVGTALS LLIRAELSQP GALLGDDQIY NVIVTAHAFV MIFFMVMPIL IGGFGNWLVP LMIGAPDMAF PRMNNMSFWL LPPSFLLLLA SSGVEAGAGT GWTVYPPLAG NLAHAGASVD LTIFSLHLAG VSSILGAINF ITTIINMKPP ATSQYQTPLF VWSVLITAVL LLLSLPVLAA GITMLLTDRN LNTT //