ID A0A1V3FXL8_9BACI Unreviewed; 472 AA. AC A0A1V3FXL8; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 13-NOV-2019, entry version 8. DE RecName: Full=Protoporphyrinogen oxidase {ECO:0000256|RuleBase:RU364052}; DE EC=1.3.3.4 {ECO:0000256|RuleBase:RU364052}; GN ORFNames=BO219_00755 {ECO:0000313|EMBL:OOE06346.1}; OS Anoxybacillus sp. 103. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus; OC unclassified Anoxybacillus. OX NCBI_TaxID=1919277 {ECO:0000313|EMBL:OOE06346.1, ECO:0000313|Proteomes:UP000188458}; RN [1] {ECO:0000313|EMBL:OOE06346.1, ECO:0000313|Proteomes:UP000188458} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=103 {ECO:0000313|EMBL:OOE06346.1, RC ECO:0000313|Proteomes:UP000188458}; RA Hovhannisyan P., Panosyan H., Birkeland N.-K.; RT "Draft genome sequence of Anoxybacillus sp. strain 103 isolated from RT the Qarvajar hot spring in Nagorno-Karabach."; RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the 6-electron oxidation of CC protoporphyrinogen-IX to form protoporphyrin-IX. CC {ECO:0000256|RuleBase:RU364052}. CC -!- CATALYTIC ACTIVITY: CC Reaction=3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin CC IX; Xref=Rhea:RHEA:25576, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, CC ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.3.4; CC Evidence={ECO:0000256|RuleBase:RU364052}; CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|RuleBase:RU364052}; CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin- CC IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: CC step 1/1. {ECO:0000256|RuleBase:RU364052}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364052}. CC -!- SIMILARITY: Belongs to the protoporphyrinogen oxidase family. CC {ECO:0000256|RuleBase:RU364052}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:OOE06346.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MQAD01000001; OOE06346.1; -; Genomic_DNA. DR UniPathway; UPA00251; UER00324. DR Proteomes; UP000188458; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0004729; F:oxygen-dependent protoporphyrinogen oxidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 3.50.50.60; -; 1. DR InterPro; IPR002937; Amino_oxidase. DR InterPro; IPR036188; FAD/NAD-bd_sf. DR InterPro; IPR004572; Protoporphyrinogen_oxidase. DR Pfam; PF01593; Amino_oxidase; 1. DR SUPFAM; SSF51905; SSF51905; 1. DR TIGRFAMs; TIGR00562; proto_IX_ox; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000188458}; KW Cytoplasm {ECO:0000256|RuleBase:RU364052}; KW FAD {ECO:0000256|RuleBase:RU364052}; KW Flavoprotein {ECO:0000256|RuleBase:RU364052}; KW Oxidoreductase {ECO:0000256|RuleBase:RU364052}; KW Porphyrin biosynthesis {ECO:0000256|RuleBase:RU364052}. FT DOMAIN 12 460 Amino_oxidase. {ECO:0000259|Pfam: FT PF01593}. SQ SEQUENCE 472 AA; 52663 MW; F3EFE74872B24248 CRC64; MKKKVVIIGG GMTGLAAAYY LQKEAREKQL PISCELIEAS HRLGGKVQTV YRDGFVIERG PDSFLARKMS ASRLIHEVGL EKELVHNTAG QSYILVNRTL HPIPSGAVMG IPTKLAPFVV TRLFSPFGKL RAAADFVLPP LKTKGDVSLG QFFRRRLGNE VVDRLIEPLL SGIYAGDIDQ LSLMATFPQY FHLEQKHGSL VLGMKRSMPK QKTKQKSDKG IFQTLKTGLA SLVDAIEQRL EKGTVHKGVR VERIEKVEER YVLTLSNGEK KEADSVVVAV PHQSLPSLFP NETMFSSFET MPSTSVATVA LAFPKEAVAK DMNGTGFVVS RDSDYTITAC TWTHKKWPHT TPEGYVLLRC YVGRPGDEAI VDQTDEDIVQ VVMDDLNKVM NITMNPMFSI VTRWKQSMPQ YTVGHRERME RVKQHMQQHL PGIFLAGSSY EGLGLPDCID QGEEAVKKVL HYLAYTKEKV SL //