ID A0A1V2SAP3_9BACI Unreviewed; 436 AA. AC A0A1V2SAP3; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 13-SEP-2023, entry version 20. DE RecName: Full=GTPase Der {ECO:0000256|ARBA:ARBA00020953, ECO:0000256|HAMAP-Rule:MF_00195}; DE AltName: Full=GTP-binding protein EngA {ECO:0000256|HAMAP-Rule:MF_00195}; GN Name=der {ECO:0000256|HAMAP-Rule:MF_00195}; GN ORFNames=BLX87_18470 {ECO:0000313|EMBL:ONK21894.1}; OS Bacillus sp. VT-16-64. OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1917019 {ECO:0000313|EMBL:ONK21894.1}; RN [1] {ECO:0000313|EMBL:ONK21894.1, ECO:0000313|Proteomes:UP000188748} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VT-16-64 {ECO:0000313|EMBL:ONK21894.1}; RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: GTPase that plays an essential role in the late steps of CC ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00195, CC ECO:0000256|RuleBase:RU004481}. CC -!- SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000256|HAMAP- CC Rule:MF_00195}. CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like CC GTPase superfamily. EngA (Der) GTPase family. CC {ECO:0000256|ARBA:ARBA00008279, ECO:0000256|HAMAP-Rule:MF_00195, CC ECO:0000256|PROSITE-ProRule:PRU01049, ECO:0000256|RuleBase:RU004481}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ONK21894.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MSRF01000257; ONK21894.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1V2SAP3; -. DR EnsemblBacteria; ONK21894; ONK21894; BLX87_18470. DR OrthoDB; 9805918at2; -. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. DR CDD; cd01894; EngA1; 1. DR CDD; cd01895; EngA2; 1. DR Gene3D; 3.30.300.20; -; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR HAMAP; MF_00195; GTPase_Der; 1. DR InterPro; IPR031166; G_ENGA. DR InterPro; IPR006073; GTP-bd. DR InterPro; IPR016484; GTPase_Der. DR InterPro; IPR032859; KH_dom-like. DR InterPro; IPR015946; KH_dom-like_a/b. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR005225; Small_GTP-bd_dom. DR NCBIfam; TIGR03594; GTPase_EngA; 1. DR NCBIfam; TIGR00231; small_GTP; 2. DR PANTHER; PTHR43834:SF6; GTP-BINDING PROTEIN ENGA; 1. DR PANTHER; PTHR43834; GTPASE DER; 1. DR Pfam; PF14714; KH_dom-like; 1. DR Pfam; PF01926; MMR_HSR1; 2. DR PIRSF; PIRSF006485; GTP-binding_EngA; 1. DR PRINTS; PR00326; GTP1OBG. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR PROSITE; PS51712; G_ENGA; 2. PE 3: Inferred from homology; KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP- KW Rule:MF_00195}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00195}; KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU004481}; KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP- KW Rule:MF_00195}. FT DOMAIN 4..167 FT /note="EngA-type G" FT /evidence="ECO:0000259|PROSITE:PS51712" FT DOMAIN 176..351 FT /note="EngA-type G" FT /evidence="ECO:0000259|PROSITE:PS51712" FT BINDING 10..17 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" FT BINDING 57..61 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" FT BINDING 119..122 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="1" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" FT BINDING 182..189 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" FT BINDING 229..233 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" FT BINDING 294..297 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /ligand_label="2" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00195" SQ SEQUENCE 436 AA; 48760 MW; FF73E205539C4A3A CRC64; MGMPTVAIVG RPNVGKSTIF NRIVGERISI VEDEPGVTRD RIYGTGEWLT TYFHVIDTGG IDIGDAPFLE EVRQQAEIAI EEADVIIFIV NSREGVTSAD EEVAKILFRS KKPVVLAVNK VDNPEMRSQI YDFYSLGFGE PFPISGSHGL GLGDLLDEVI KHFPADHGDP YDEDVIKFSL IGRPNVGKSS LVNALLGEER VIVSPIAGTT RDAVDTPYIV DGQEYVIIDT AGMRKRGKVY ESTEKYSVLR ALKAIERSDV VLVVLDGEEG IREQDKRIAG YAHEAGRAII IVVNKWDAVE KDEKTMRNFE EKIRDQFQFL DYAPIVFLSA KTKKRIGTLL PAIQMASENH ARRVQSSVLN EVILDAAAMN PAPADKGKRL KVYYATQVSV KPPTFVVFVN EPELMHFSYE RFLRNTIRQA FEFEGTPLKI IARKRK //