ID A0A1U9WRJ0_9CAUD Unreviewed; 608 AA. AC A0A1U9WRJ0; DT 07-JUN-2017, integrated into UniProtKB/TrEMBL. DT 07-JUN-2017, sequence version 1. DT 12-OCT-2022, entry version 18. DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417}; DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417}; GN Name=45 {ECO:0000313|EMBL:AQY55463.1}; GN ORFNames=PBI_TINAFEYGE_45 {ECO:0000313|EMBL:AQY55463.1}; OS Mycobacterium phage TinaFeyge. OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; OC Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus. OX NCBI_TaxID=1958911 {ECO:0000313|EMBL:AQY55463.1, ECO:0000313|Proteomes:UP000222747}; RN [1] {ECO:0000313|Proteomes:UP000222747} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, CC ChEBI:CHEBI:173112; EC=2.7.7.7; CC Evidence={ECO:0000256|ARBA:ARBA00024632}; CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family. CC {ECO:0000256|ARBA:ARBA00007705}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY471266; AQY55463.1; -; Genomic_DNA. DR Proteomes; UP000222747; Genome. DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC. DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro. DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW. DR Gene3D; 3.30.420.10; -; 1. DR InterPro; IPR002562; 3'-5'_exonuclease_dom. DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS. DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR002298; DNA_polymerase_A. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR PANTHER; PTHR10133; PTHR10133; 1. DR Pfam; PF00476; DNA_pol_A; 1. DR Pfam; PF01612; DNA_pol_A_exo1; 1. DR PRINTS; PR00868; DNAPOLI. DR SMART; SM00474; 35EXOc; 1. DR SMART; SM00482; POLAc; 1. DR SUPFAM; SSF53098; SSF53098; 1. DR SUPFAM; SSF56672; SSF56672; 1. DR PROSITE; PS00447; DNA_POLYMERASE_A; 1. PE 3: Inferred from homology; KW DNA replication {ECO:0000256|ARBA:ARBA00023109}; KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}. FT DOMAIN 15..211 FT /note="3'-5' exonuclease" FT /evidence="ECO:0000259|SMART:SM00474" FT DOMAIN 372..568 FT /note="POLAc" FT /evidence="ECO:0000259|SMART:SM00482" SQ SEQUENCE 608 AA; 67717 MW; DA297B911B22C741 CRC64; MIEHRHEVDG DEVVINVVDR ESDLDGFMDF IRAHQGFLGL DSETTGLDIY NDGFRCRLVQ FGTPSEAWVV PVERGGPYAG DVKRALEMVQ GFVLHNAAYD LQVFERTLGV PMETMWPKVK DTRILAHLID PRGKDEGGSG HSLEDLTRRY IDSAVADNVK TLMADLAKAN KTTKVNVWKK VPFEDPHYQL YSGMDPILAA RLIQKLAPLV KVSDELVDNE HKLAAICSYM ERTGFLLDVE YTEELSLDLQ VKESHYNEIA LNYGCEKVNS TDQVADVLES MGVRIKGRTP SGKRKVDDAV LSELVEHEKA GEFATAVIEA KKAGKWRKTW VDGFLKQRDS QNRCHAAINP LRARTARMSI TGIPAQTLPA GDSTIRRCFL ADEGHRIASV DYQAQELRVL AALSKDQRMI QAFLDDADLH LMTARAAFGE HIQKDDPERK YAKVVNFGRV YGGGAKTVAE QTGLDMATAQ KVVAGFDRAY PEVQKLSQRL QREAIRNGYI TTPFIDGLGG RRLPVDPQRA YSALNYLIQS SSRDVTCRAL LRLHDAGFTP YLRLPIHDEI LASVPAEQAE WGANRIGELM AEQMGPVLIG TDPEVGGRSW GSLYGANY //