ID A0A1U7SB91_ALLSI Unreviewed; 538 AA. AC A0A1U7SB91; DT 10-MAY-2017, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 2. DT 27-MAR-2024, entry version 28. DE RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 1 {ECO:0000256|ARBA:ARBA00039600}; DE EC=3.6.1.5 {ECO:0000256|ARBA:ARBA00012148}; DE AltName: Full=ATP diphosphohydrolase {ECO:0000256|ARBA:ARBA00044314}; DE AltName: Full=Ecto-ATP diphosphohydrolase 1 {ECO:0000256|ARBA:ARBA00042147}; DE AltName: Full=Ecto-apyrase {ECO:0000256|ARBA:ARBA00042196}; DE AltName: Full=Lymphoid cell activation antigen {ECO:0000256|ARBA:ARBA00041335}; DE AltName: Full=Nucleoside triphosphate diphosphohydrolase 1 {ECO:0000256|ARBA:ARBA00044280}; GN Name=ENTPD1 {ECO:0000313|RefSeq:XP_006038142.3}; OS Alligator sinensis (Chinese alligator). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae; OC Alligator. OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006038142.3}; RN [1] {ECO:0000313|RefSeq:XP_006038142.3} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=2 H2O + ITP = 2 H(+) + IMP + 2 phosphate; CC Xref=Rhea:RHEA:77735, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; CC Evidence={ECO:0000256|ARBA:ARBA00043682}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:77736; CC Evidence={ECO:0000256|ARBA:ARBA00043682}; CC -!- CATALYTIC ACTIVITY: CC Reaction=2 H2O + UTP = 2 H(+) + 2 phosphate + UMP; CC Xref=Rhea:RHEA:64896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:46398, ChEBI:CHEBI:57865; CC Evidence={ECO:0000256|ARBA:ARBA00043678}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64897; CC Evidence={ECO:0000256|ARBA:ARBA00043678}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ADP + H2O = AMP + H(+) + phosphate; Xref=Rhea:RHEA:61436, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; CC Evidence={ECO:0000256|ARBA:ARBA00036139}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61437; CC Evidence={ECO:0000256|ARBA:ARBA00036139}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate; CC Xref=Rhea:RHEA:20988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456215; CC Evidence={ECO:0000256|ARBA:ARBA00043702}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20989; CC Evidence={ECO:0000256|ARBA:ARBA00043702}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; CC Evidence={ECO:0000256|ARBA:ARBA00034440}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066; CC Evidence={ECO:0000256|ARBA:ARBA00034440}; CC -!- CATALYTIC ACTIVITY: CC Reaction=CDP + H2O = CMP + H(+) + phosphate; Xref=Rhea:RHEA:64880, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58069, ChEBI:CHEBI:60377; CC Evidence={ECO:0000256|ARBA:ARBA00043676}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64881; CC Evidence={ECO:0000256|ARBA:ARBA00043676}; CC -!- CATALYTIC ACTIVITY: CC Reaction=CTP + 2 H2O = CMP + 2 H(+) + 2 phosphate; CC Xref=Rhea:RHEA:64908, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:60377; CC Evidence={ECO:0000256|ARBA:ARBA00043680}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64909; CC Evidence={ECO:0000256|ARBA:ARBA00043680}; CC -!- CATALYTIC ACTIVITY: CC Reaction=CTP + H2O = CDP + H(+) + phosphate; Xref=Rhea:RHEA:29387, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58069; CC Evidence={ECO:0000256|ARBA:ARBA00043776}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29388; CC Evidence={ECO:0000256|ARBA:ARBA00043776}; CC -!- CATALYTIC ACTIVITY: CC Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; CC Evidence={ECO:0000256|ARBA:ARBA00043654}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22157; CC Evidence={ECO:0000256|ARBA:ARBA00043654}; CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate; CC Xref=Rhea:RHEA:64904, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115; CC Evidence={ECO:0000256|ARBA:ARBA00043766}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64905; CC Evidence={ECO:0000256|ARBA:ARBA00043766}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + IDP = H(+) + IMP + phosphate; Xref=Rhea:RHEA:35207, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58053, ChEBI:CHEBI:58280; CC Evidence={ECO:0000256|ARBA:ARBA00043688}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:35208; CC Evidence={ECO:0000256|ARBA:ARBA00043688}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; CC Evidence={ECO:0000256|ARBA:ARBA00043752}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28331; CC Evidence={ECO:0000256|ARBA:ARBA00043752}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + UDP = H(+) + phosphate + UMP; Xref=Rhea:RHEA:64876, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57865, ChEBI:CHEBI:58223; CC Evidence={ECO:0000256|ARBA:ARBA00043716}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64877; CC Evidence={ECO:0000256|ARBA:ARBA00043716}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + UTP = H(+) + phosphate + UDP; Xref=Rhea:RHEA:64900, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:46398, ChEBI:CHEBI:58223; CC Evidence={ECO:0000256|ARBA:ARBA00043661}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64901; CC Evidence={ECO:0000256|ARBA:ARBA00043661}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'- CC phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; CC Evidence={ECO:0000256|ARBA:ARBA00043714}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36800; CC Evidence={ECO:0000256|ARBA:ARBA00043714}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside CC 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5; CC Evidence={ECO:0000256|ARBA:ARBA00043753}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36796; CC Evidence={ECO:0000256|ARBA:ARBA00043753}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; CC Evidence={ECO:0000256|ARBA:ARBA00043686}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23681; CC Evidence={ECO:0000256|ARBA:ARBA00043686}; CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|ARBA:ARBA00001913}; CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family. CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006038142.3; XM_006038080.3. DR AlphaFoldDB; A0A1U7SB91; -. DR STRING; 38654.A0A1U7SB91; -. DR KEGG; asn:102373368; -. DR eggNOG; KOG1386; Eukaryota. DR InParanoid; A0A1U7SB91; -. DR OrthoDB; 180318at2759; -. DR Proteomes; UP000189705; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 1. DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1. DR InterPro; IPR000407; GDA1_CD39_NTPase. DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1. DR PANTHER; PTHR11782:SF32; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1; 1. DR Pfam; PF01150; GDA1_CD39; 1. DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2}; KW Hydrolase {ECO:0000256|RuleBase:RU003833}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000189705}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 43..64 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 503..527 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT ACT_SITE 201 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1" FT BINDING 242..246 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2" SQ SEQUENCE 538 AA; 59355 MW; EA2C74CF1994C0F8 CRC64; MCTSQSGSLA PAEAEKGGGE RALVLMDEPK GAKPKMASAK PKMAVLILGS LFVLAVIALI TVAVTQNQWL PKNIKYGIVL DAGSSHTNLY VYAWPAEKEN DTGVVQQVEV CKVEGPGISG YSQAVQNASR SLQHCLERAQ EVVPQQQHQE TPVYLGATAG MRLLSLDNRH VAMEVLSAVE NKLRSSPFNF QGARIITGQE EGAYGWITIN YLLGSFKQSG WLNFLPKLTS IKETVGALDL GGASTQITFV PEQEQSESQE NSLHFRLYGK SYNVYTHSFL CYGKDQALRM KLVRDLQNAE TGRLQDPCFH TGYERNVSIR DLYASPCTAN YKQSLAFPQL HVVGSGDYQA CQTRIEELFN KTSCPYSKCS FNGIFLPPLQ GHFGAFSAFY FVMNFLNLSA ESSPAPLNSA ISTMKNFCSR PWSEVKAAYP QVKEKYLSEY CFSGTYIISL LKTGYGFSLE TWQQIQFLGK IGSSDAGWTL GYMLNLTNMI PAEQSLMRPL SHAGYVGLMV LSSLVLVGAL LLGWCIFRKP RCLRKGIV //