ID   A0A1U7QUQ6_MESAU        Unreviewed;       359 AA.
AC   A0A1U7QUQ6;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   02-OCT-2024, entry version 37.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   Name=Ptpn7 {ECO:0000313|RefSeq:XP_005073447.1,
GN   ECO:0000313|RefSeq:XP_021084806.1, ECO:0000313|RefSeq:XP_021084808.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_005073447.1};
RN   [1] {ECO:0000313|RefSeq:XP_005073447.1, ECO:0000313|RefSeq:XP_021084806.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2024) to UniProtKB.
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DR   RefSeq; XP_005073447.1; XM_005073390.3.
DR   RefSeq; XP_021084806.1; XM_021229147.1.
DR   RefSeq; XP_021084808.1; XM_021229149.1.
DR   STRING; 10036.ENSMAUP00000021384; -.
DR   KEGG; maua:101827672; -.
DR   eggNOG; KOG0789; Eukaryota.
DR   OrthoDB; 2914248at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0030054; C:cell junction; IEA:TreeGrafter.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR   CDD; cd14612; PTPc-N7; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR008356; Tyr_Pase_KIM-con.
DR   PANTHER; PTHR46198; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR   PANTHER; PTHR46198:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR01778; KIMPTPASE.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT   DOMAIN          97..349
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          265..340
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        290
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
FT   BINDING         257
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT   BINDING         290..296
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT   BINDING         334
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
SQ   SEQUENCE   359 AA;  40320 MW;  682487D948E5AFCA CRC64;
     MVQTCEECSR PQPPTLSLGE AMTQPPPTKA PAKKHVRLQE RRGSSVALML DVRSLGTVEP
     ICSVSTPREV TIHFLRTAGH PLTCWGLQHQ PPSPKQLEEE FLKIPSNFVN PEDLDIPGHA
     SKDRYKTILP NPQSRVCLGR AQSQEDGDYI NANYIRGYDG QEKVYIATQG PMPNTVADFW
     EMVWQEEVGL IVMLTQLREG KEKCVHYWPT EEETYGPFQI RIQDMKEHPE YTVRQLTIQH
     QKECRSVKHI LFSAWPDHQT PESAGPLLRL VAEVESPETA ANSGPIVVHC SAGIGRTGCF
     IATRIGCQQL KARGEVDILG IVCRLRLDRG GMIQTAEQYQ FLHHTLALYA AQLSQEPSP
//