ID A0A1U6ZEY4_CENAU Unreviewed; 324 AA. AC A0A1U6ZEY4; DT 10-MAY-2017, integrated into UniProtKB/TrEMBL. DT 10-MAY-2017, sequence version 1. DT 02-OCT-2024, entry version 27. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU000473}; GN Name=ND1 {ECO:0000313|EMBL:AKS03568.1}; OS Centropyge aurantia (Golden angelfish). OG Mitochondrion {ECO:0000313|EMBL:AKS03568.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Pomacanthidae; Centropyge. OX NCBI_TaxID=466111 {ECO:0000313|EMBL:AKS03568.1}; RN [1] {ECO:0000313|EMBL:AKS03568.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Muscle {ECO:0000313|EMBL:AKS03568.1}; RA Shen K.-N., Hsiao C.-D.; RT "Next generation sequencing yields the complete mitochondrial genome of the RT Golden angelfish, Centropyge aurantius (Perciformes: Pomacanthidae)."; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KP973959; AKS03568.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1U6ZEY4; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:AKS03568.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU000471}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 6..29 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 75..95 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 107..129 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 150..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 177..194 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 237..254 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 260..279 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 299..320 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 324 AA; 35707 MW; 0EF4218F06749F6E CRC64; MISTLITHIL NPLAFIVPVL LAVAFLTLLE RKVLGYMQAR KGPNIVGPHG ILQPISDGAK LFTKEPIRPL TSSSFLFLIT PIMALTLALT LWAPLPMPHP VIDLNLGILF IIALSSLAVY SILGSGWASN SKYALLGALR AVAQTISYEV SLGLILLNAV ILTGNFTLQT FSTAQESMWL ILPTWPLAAM WYISTLAETN RAPFDLTEGE SELVSGFNVE YAGGPFALFF LAEYSNILFM NTLSAILFMG ATYFPSLPMF TTANLMTKAA LLSLVFLWVR ASYPRFRYDQ LMHLIWKNFL PLTLALIIWH LAMPIALAGL PPQM //