ID A0A1S6K7V5_9DINO Unreviewed; 1445 AA. AC A0A1S6K7V5; DT 10-MAY-2017, integrated into UniProtKB/TrEMBL. DT 10-MAY-2017, sequence version 1. DT 27-MAR-2024, entry version 22. DE RecName: Full=beta-ketoacyl-[acyl-carrier-protein] synthase III {ECO:0000256|ARBA:ARBA00012333}; DE EC=2.3.1.180 {ECO:0000256|ARBA:ARBA00012333}; OS Gambierdiscus polynesiensis. OC Eukaryota; Sar; Alveolata; Dinophyceae; Gonyaulacales; Pyrocystaceae; OC Gambierdiscus. OX NCBI_TaxID=439318 {ECO:0000313|EMBL:AQS99299.1}; RN [1] {ECO:0000313|EMBL:AQS99299.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Contig_45732 {ECO:0000313|EMBL:AQS99299.1}; RX PubMed=28211202; RA Kohli G.S., Campbell K., John U., Smith K.F., Fraga S., Rhodes L.L., RA Murray S.A.; RT "Role of Modular Polyketide Synthases in the Production of Polyether Ladder RT Compounds in Ciguatoxin-producing Gambierdiscus polynesiensis and RT G.excentricus (Dinophyceae)."; RL J. Eukaryot. Microbiol. 0:0-0(2017). CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC {ECO:0000256|ARBA:ARBA00005194}. CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family. CC {ECO:0000256|ARBA:ARBA00008642}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX395881; AQS99299.1; -; Transcribed_RNA. DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. DR CDD; cd00830; KAS_III; 1. DR Gene3D; 3.40.47.10; -; 1. DR HAMAP; MF_01815; FabH; 1. DR InterPro; IPR013747; ACP_syn_III_C. DR InterPro; IPR013751; ACP_syn_III_N. DR InterPro; IPR004655; FabH. DR InterPro; IPR016039; Thiolase-like. DR NCBIfam; TIGR00747; fabH; 1. DR PANTHER; PTHR43091; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE; 1. DR PANTHER; PTHR43091:SF1; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III, CHLOROPLASTIC; 1. DR Pfam; PF08545; ACP_syn_III; 1. DR Pfam; PF08541; ACP_syn_III_C; 1. DR SUPFAM; SSF53901; Thiolase-like; 1. PE 3: Inferred from homology; KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 1162..1243 FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III N- FT terminal" FT /evidence="ECO:0000259|Pfam:PF08545" FT DOMAIN 1305..1394 FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C- FT terminal" FT /evidence="ECO:0000259|Pfam:PF08541" FT REGION 166..185 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 258..281 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 398..427 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 467..491 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 610..688 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1417..1445 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 652..676 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1445 AA; 149881 MW; DD7EF4FE561C1E1C CRC64; MTGVRRREHG ASTVHSAGPR WCAEELSVRV QEPAAMSKEV WNAELAARAL PGPLDYQVVH TVPASVRERP TPQAQELGRI SPGCVVIGFP GKGWLRLCQG GAPCVERGLE GGWVFIGNRL EATCMKVSLQ QSSAEAVSVV WKGLSTKRVG YSIEWQPLHL AQNTDSVGQT KDFSGRQRGF SNTTGTSPAV TLATLGRSGH MVTREPVAFL SGLASGTTYR VRAAARLFAA ASSGADDVRV LGPWCIVETG STCSDDLTGT DTESRCGRGG NGSDGGARSS AVSASALRMA TDETTLSDAD VHEVCSPGHR PIQGLGALMR NPVLAVVANP PADAPIQGES ESSASNLKVI TPRTVAQQTT SGGLTIGRKR PPPCVARSPA MTCEGAPAAK LSGSIAKNTE QSRVEEAPCK GGSCEGQGEA QVSSRSDSLR VPEAVVGGSP ALSNPGTPRN EGCLFDFHEL EARMMKLDSS EREAENDGAP TPPTTRGSGD VTVPEAVVGC AEASCDAPRD GCHVPLQAAL ASVGVPTSSN AAGADVVSPA SVATVDDLAH AAQQPAQVSA AEPVCAEVSP TSLAAGDDVG LAHAAQQPPQ VSAAEPVCAE ADMALAGVGS AHLPETGSGA VCSVSSPSTP KGSEGDPQPP VQGADSACST GAGVCSKATP TSAPRQSPSQ VPAEEEEGVS TTKRAAELAE RSLTKPLEYE IVRKGTVSAR SAPHAKAKEL GQLSSGFRVL GFPGRGWLWL RGSGGAQRLP PELVGCWVFT GCRLQSTCMR XXXSVERVVG LSSTDPDGST GGHTLCGGPR ALLCGIPAGA TVQTRAVARV MGPNKNDEDV RVLGPWSELD TGAWIPEDLE MDSKSCLDPY GNRRGGCDES KCCKFVWKNS GTSFDPRSVR CLRCGQPFHK HKKRIGLEYD DDDDDSLAFY VVSHCQVTVR SHRHLRSTAL GTLKRGARVR GVPMGRWLRL EVAPIQSLLL PLASANGANA SAWVLFDGSQ MGLGQLLEPC SLAQPLKSPP HVGAPGCPAV PQAFRPLEGG GRSSSSSGSS HLLCVPLGVG CAVPKLCITN ADLQCFVDKS DGWIRTRTGV ASRHVLGCAH AEGGDDGGDS LGDRDAGLVG LASSAAEAAL EFSGCKAADL DLVLMCTSSP EDLFGDATTV ASKIGANNAV AFDLTAACSG FLFGIVTASQ FLHTGAHRRA LVIGADALSR WVDWGDRNTS ILFGDGAGAL VLAAVEDGAE SSGLLGFAMH SDGCGHKHLR LPFCGSPHEL NAPKPMMQQQ PLSLQKGGYG SIIMNGSEVY AFAVERVPQV ILEALDNAGL SVAQVDWLVL HQANVRIIEE VARRLWIPSS KLITNIHKHG NTSAASIPLA LAEAVERGDA KFGDVIVCAG FGAGLSWGAA VLRWGTAHMA GLTPVRDRAA AAHMAGGTLP HARDPPSRRR QAAGLARGVS APPPR //