ID A0A1Q9CGT5_SYMMI Unreviewed; 290 AA. AC A0A1Q9CGT5; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 29-MAY-2024, entry version 23. DE SubName: Full=Glyoxylate/succinic semialdehyde reductase 1 {ECO:0000313|EMBL:OLP82086.1}; GN Name=GLYR1 {ECO:0000313|EMBL:OLP82086.1}; GN ORFNames=AK812_SmicGene37299 {ECO:0000313|EMBL:OLP82086.1}; OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella OS microadriatica). OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae; OC Symbiodinium. OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP82086.1, ECO:0000313|Proteomes:UP000186817}; RN [1] {ECO:0000313|EMBL:OLP82086.1, ECO:0000313|Proteomes:UP000186817} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP82086.1, RC ECO:0000313|Proteomes:UP000186817}; RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J., RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T., RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.; RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary RT adaptations to a symbiotic lifestyle."; RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily. CC {ECO:0000256|ARBA:ARBA00007598}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OLP82086.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LSRX01001225; OLP82086.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1Q9CGT5; -. DR OMA; NALGCEY; -. DR OrthoDB; 203032at2759; -. DR Proteomes; UP000186817; Unassembled WGS sequence. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IEA:TreeGrafter. DR GO; GO:0035064; F:methylated histone binding; IEA:TreeGrafter. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf. DR InterPro; IPR013328; 6PGD_dom2. DR InterPro; IPR006115; 6PGDH_NADP-bd. DR InterPro; IPR029154; HIBADH-like_NADP-bd. DR InterPro; IPR015815; HIBADH-related. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1. DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1. DR Pfam; PF14833; NAD_binding_11; 1. DR Pfam; PF03446; NAD_binding_2; 1. DR PIRSF; PIRSF000103; HIBADH; 1. DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. PE 3: Inferred from homology; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Reference proteome {ECO:0000313|Proteomes:UP000186817}. FT DOMAIN 7..163 FT /note="6-phosphogluconate dehydrogenase NADP-binding" FT /evidence="ECO:0000259|Pfam:PF03446" FT DOMAIN 168..286 FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" FT /evidence="ECO:0000259|Pfam:PF14833" FT ACT_SITE 174 FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1" SQ SEQUENCE 290 AA; 30359 MW; 8CAA1BA490FF29C5 CRC64; MDKKPSVGYL GMGIMGSAMA GRLVDAGYPV TVWNRSRDKC APLEAKGAKV SETAQEVVET CDVTFACTSD PTSARAVVFG EKGVLAGITK GKRFVDMSTV DEECVKEIAE AITAKGGRFV EAPVSGSKGP ALQGQLVILA AGEEALQKEV QPCLDVLGKR TFFLGEVGCG ARMKLVINMV MGINMVALSE GLAVGQKAGL QGKDILEVIK EGAIASPMYG LKGPKMLDGD FAPNFPLKHQ QKDVRLAVDL GDKVGQSMPL AAAANEAFKA ARAAGKGDED FSAVYATVNR //