ID A0A1Q5N8K6_9ACTN Unreviewed; 530 AA. AC A0A1Q5N8K6; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 31-JUL-2019, entry version 13. DE RecName: Full=RNA polymerase sigma factor SigA {ECO:0000256|HAMAP-Rule:MF_00963}; GN Name=sigA {ECO:0000256|HAMAP-Rule:MF_00963}; GN ORFNames=AMK16_06990 {ECO:0000313|EMBL:OKK22793.1}; OS Streptomyces sp. CB00455. OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; OC Streptomyces. OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK22793.1, ECO:0000313|Proteomes:UP000185643}; RN [1] {ECO:0000313|EMBL:OKK22793.1, ECO:0000313|Proteomes:UP000185643} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK22793.1, RC ECO:0000313|Proteomes:UP000185643}; RX PubMed=27999165; RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X., RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X., RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.; RT "Strain Prioritization and Genome Mining for Enediyne Natural RT Products."; RL MBio 7:e02104-16(2016). CC -!- FUNCTION: Sigma factors are initiation factors that promote the CC attachment of RNA polymerase to specific initiation sites and are CC then released. This sigma factor is the primary sigma factor CC during exponential growth. {ECO:0000256|HAMAP-Rule:MF_00963, CC ECO:0000256|SAAS:SAAS00535554}. CC -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic CC core. {ECO:0000256|HAMAP-Rule:MF_00963}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00963}. CC -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00963}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:OKK22793.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LIVQ01000001; OKK22793.1; -; Genomic_DNA. DR RefSeq; WP_073909856.1; NZ_LIVQ01000001.1. DR Proteomes; UP000185643; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0001123; P:transcription initiation from bacterial-type RNA polymerase promoter; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.10.10; -; 2. DR HAMAP; MF_00963; Sigma70_RpoD_SigA; 1. DR InterPro; IPR014284; RNA_pol_sigma-70_dom. DR InterPro; IPR000943; RNA_pol_sigma70. DR InterPro; IPR009042; RNA_pol_sigma70_r1_2. DR InterPro; IPR007627; RNA_pol_sigma70_r2. DR InterPro; IPR007624; RNA_pol_sigma70_r3. DR InterPro; IPR007630; RNA_pol_sigma70_r4. DR InterPro; IPR013325; RNA_pol_sigma_r2. DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like. DR InterPro; IPR012760; RNA_pol_sigma_RpoD_C. DR InterPro; IPR028630; Sigma70_RpoD. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR Pfam; PF00140; Sigma70_r1_2; 1. DR Pfam; PF04542; Sigma70_r2; 1. DR Pfam; PF04539; Sigma70_r3; 1. DR Pfam; PF04545; Sigma70_r4; 1. DR PRINTS; PR00046; SIGMA70FCT. DR SUPFAM; SSF88659; SSF88659; 2. DR SUPFAM; SSF88946; SSF88946; 1. DR TIGRFAMs; TIGR02393; RpoD_Cterm; 1. DR TIGRFAMs; TIGR02937; sigma70-ECF; 1. DR PROSITE; PS00715; SIGMA70_1; 1. DR PROSITE; PS00716; SIGMA70_2; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000185643}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00963}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00963, KW ECO:0000256|SAAS:SAAS00611263}; KW Reference proteome {ECO:0000313|Proteomes:UP000185643}; KW Sigma factor {ECO:0000256|HAMAP-Rule:MF_00963, KW ECO:0000256|SAAS:SAAS00611278}; KW Transcription {ECO:0000256|HAMAP-Rule:MF_00963, KW ECO:0000256|SAAS:SAAS00611290}; KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00963, KW ECO:0000256|SAAS:SAAS00611294}. FT DOMAIN 321 334 RNA_pol_sigma70. {ECO:0000259|PROSITE: FT PS00715}. FT DOMAIN 490 516 RNA_pol_sigma70. {ECO:0000259|PROSITE: FT PS00716}. FT DNA_BIND 491 510 H-T-H motif. {ECO:0000256|HAMAP-Rule: FT MF_00963}. FT REGION 75 218 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 297 367 Sigma-70 factor domain-2. FT {ECO:0000256|HAMAP-Rule:MF_00963}. FT REGION 376 452 Sigma-70 factor domain-3. FT {ECO:0000256|HAMAP-Rule:MF_00963}. FT REGION 465 518 Sigma-70 factor domain-4. FT {ECO:0000256|HAMAP-Rule:MF_00963}. FT MOTIF 321 324 Interaction with polymerase core subunit FT RpoC. {ECO:0000256|HAMAP-Rule:MF_00963}. FT COMPBIAS 148 171 Basic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 172 193 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 201 215 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. SQ SEQUENCE 530 AA; 57850 MW; A7FD5E565D80535F CRC64; MFVSASTSRT LPPEIADSES VMALIERGKA EGQIAGDDVR RAFEADQIPA TQWKNVLRSL NQILEEEGVT LMVSAAESPK RTTRKSVAAK SPAKRTATEP VARKTAARTT AAHTAAPAAP EAETADPQTV DALAEEPGTE APAKKTVAKK AAAKKAAPAK KTAAKKTAAK KTASKKAADD TGDEETPEEG PDAAKADGDE EEEGGENKGF VISDDEDDAP AQQVVVAGAT ADPVKDYLKQ IGKVPLLNAE QEVELAKRIE AGLFAEDKLA NSDKLAPKLK RELEIIAEDG RRAKNHLLEA NLRLVVSLAK RYTGRGMLFL DLIQEGNLGL IRAVEKFDYT KGYKFSTYAT WWIRQAITRA MADQARTIRI PVHMVEVINK LARVQRQMLQ DLGREPTPEE LAKELDMTPE KVIEVQKYGR EPISLHTPLG EDGDSEFGDL IEDSEAVVPA DAVSFTLLQE QLHSVLDTLS EREAGVVSMR FGLTDGQPKT LDEIGKVYGV TRERIRQIES KTMSKLRHPS RSQVLRDYLD //