ID A0A1P8NNT1_9SALA Unreviewed; 243 AA. AC A0A1P8NNT1; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 25-OCT-2017, entry version 4. DE RecName: Full=Cytochrome b {ECO:0000256|RuleBase:RU362117}; DE Flags: Fragment; OS Eurycea lucifuga (cave salamander). OG Mitochondrion {ECO:0000313|EMBL:APX41184.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Caudata; Salamandroidea; Plethodontidae; OC Hemidactyliinae; Eurycea. OX NCBI_TaxID=422567 {ECO:0000313|EMBL:APX41184.1}; RN [1] {ECO:0000313|EMBL:APX41184.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BF7_18_2 {ECO:0000313|EMBL:APX41184.1}; RC TISSUE=Tail clips {ECO:0000313|EMBL:APX41184.1}; RA Edgington H.A., Ingram C.M., Taylor D.R.; RT "Phylogeography implicates Pleistocene divergence in a cave-dwelling RT salamander lineage, Eurycea lucifuga."; RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the ubiquinol-cytochrome c reductase CC complex (complex III or cytochrome b-c1 complex) that is part of CC the mitochondrial respiratory chain. The b-c1 complex mediates CC electron transfer from ubiquinol to cytochrome c. Contributes to CC the generation of a proton gradient across the mitochondrial CC membrane that is then used for ATP synthesis. CC {ECO:0000256|RuleBase:RU362117}. CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|RuleBase:RU362117}; CC Note=Binds 2 heme groups non-covalently. CC {ECO:0000256|RuleBase:RU362117}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU362117}. CC -!- SIMILARITY: Belongs to the cytochrome b family. CC {ECO:0000256|RuleBase:RU362117}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX148759; APX41184.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro. DR CDD; cd00284; Cytochrome_b_N; 1. DR Gene3D; 1.20.810.10; -; 1. DR InterPro; IPR005798; Cyt_b/b6_C. DR InterPro; IPR036150; Cyt_b/b6_C_sf. DR InterPro; IPR005797; Cyt_b/b6_N. DR InterPro; IPR027387; Cytb/b6-like. DR InterPro; IPR016174; Di-haem_cyt_TM. DR Pfam; PF00032; Cytochrom_B_C; 1. DR Pfam; PF00033; Cytochrome_B; 1. DR SUPFAM; SSF81342; SSF81342; 1. DR SUPFAM; SSF81648; SSF81648; 1. DR PROSITE; PS51003; CYTB_CTER; 1. DR PROSITE; PS51002; CYTB_NTER; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU362117}; KW Heme {ECO:0000256|RuleBase:RU362117}; KW Iron {ECO:0000256|RuleBase:RU362117}; KW Membrane {ECO:0000256|RuleBase:RU362117}; KW Metal-binding {ECO:0000256|RuleBase:RU362117}; KW Mitochondrion {ECO:0000256|RuleBase:RU362117, KW ECO:0000313|EMBL:APX41184.1}; KW Respiratory chain {ECO:0000256|RuleBase:RU362117}; KW Transmembrane {ECO:0000256|RuleBase:RU362117}; KW Transmembrane helix {ECO:0000256|RuleBase:RU362117}; KW Transport {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 22 43 Helical. {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 55 73 Helical. {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 79 97 Helical. {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 118 139 Helical. {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 169 191 Helical. {ECO:0000256|RuleBase:RU362117}. FT TRANSMEM 212 242 Helical. {ECO:0000256|RuleBase:RU362117}. FT DOMAIN 1 149 CYTB_NTER. {ECO:0000259|PROSITE:PS51002}. FT DOMAIN 150 243 CYTB_CTER. {ECO:0000259|PROSITE:PS51003}. FT NON_TER 1 1 {ECO:0000313|EMBL:APX41184.1}. FT NON_TER 243 243 {ECO:0000313|EMBL:APX41184.1}. SQ SEQUENCE 243 AA; 27238 MW; EA65AA3B167D4344 CRC64; SAFSSVAHIC RDVNYGWLVR SIHTNGASIF FICIYLHIGR GLYYGSYMFK ETWNIGVILL FLVMATAFVG YVLPWGQMSF WGATVITNLL SAIPYLGDTL VQWIWGGFSV EKATLTRFFA FHFILPFMIA GASIVHLLFL HETGSNNPTG LNSDPDKIPF HPYYSYKDLL GLLVMLLLLI IISLLTPNLL GDPENFTPAN PLITPPHIQP EWYFLFAYAI LRSIPNKLGG VMALLASILI LMI //