ID A0A1P8CXM8_9CETA Unreviewed; 98 AA. AC A0A1P8CXM8; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 16-JAN-2019, entry version 6. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004419}; GN Name=ND4L {ECO:0000313|EMBL:APD27955.1}; OS Bison schoetensacki. OG Mitochondrion {ECO:0000313|EMBL:APD27955.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bison. OX NCBI_TaxID=1920185 {ECO:0000313|EMBL:APD27955.1}; RN [1] {ECO:0000313|EMBL:APD27955.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28187706; RA Palacio P., Berthonaud V., Guerin C., Lambourdiere J., Maksud F., RA Philippe M., Plaire D., Stafford T., Marsolier-Kergoat M.C., RA Elalouf J.M.; RT "Genome data on the extinct Bison schoetensacki establish it as a RT sister species of the extant European bison (Bison bonasus)."; RL BMC Evol. Biol. 17:48-48(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU004419}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU004419}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU004419}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU886087; APD27955.1; -; Genomic_DNA. DR SMR; A0A1P8CXM8; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434; PTHR11434; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|RuleBase:RU004419, KW ECO:0000313|EMBL:APD27955.1}; NAD {ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004419}; KW Transport {ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 6 22 Helical. {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 29 49 Helical. {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 61 81 Helical. {ECO:0000256|RuleBase:RU004419}. SQ SEQUENCE 98 AA; 10797 MW; 4DB48B7DA59C1881 CRC64; MSMVYMNIMM AFTVSLVGLL MYRSHLMSSL LCLEGMMLSL FVMAALTILN SHFTLASMMP IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC //