ID A0A1P8CXM8_9CETA Unreviewed; 98 AA. AC A0A1P8CXM8; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 24-JAN-2024, entry version 22. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|ARBA:ARBA00016612, ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004419}; GN Name=ND4L {ECO:0000313|EMBL:APD27955.1}; OS Bison schoetensacki. OG Mitochondrion {ECO:0000313|EMBL:APD27955.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bison. OX NCBI_TaxID=1920185 {ECO:0000313|EMBL:APD27955.1}; RN [1] {ECO:0000313|EMBL:APD27955.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28187706; RA Palacio P., Berthonaud V., Guerin C., Lambourdiere J., Maksud F., RA Philippe M., Plaire D., Stafford T., Marsolier-Kergoat M.C., Elalouf J.M.; RT "Genome data on the extinct Bison schoetensacki establish it as a sister RT species of the extant European bison (Bison bonasus)."; RL BMC Evol. Biol. 17:48-48(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. {ECO:0000256|ARBA:ARBA00024311, CC ECO:0000256|RuleBase:RU004419}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004419}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000256|ARBA:ARBA00024376}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU004419}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|ARBA:ARBA00010519, ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU886087; APD27955.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1P8CXM8; -. DR SMR; A0A1P8CXM8; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.287.3510; -; 1. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434:SF0; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L; 1. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|RuleBase:RU004419, ECO:0000313|EMBL:APD27955.1}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU004419}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU004419}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 6..22 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 61..81 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" SQ SEQUENCE 98 AA; 10797 MW; 4DB48B7DA59C1881 CRC64; MSMVYMNIMM AFTVSLVGLL MYRSHLMSSL LCLEGMMLSL FVMAALTILN SHFTLASMMP IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC //