ID A0A1P8A7E8_9ALPC Unreviewed; 437 AA. AC A0A1P8A7E8; DT 12-APR-2017, integrated into UniProtKB/TrEMBL. DT 12-APR-2017, sequence version 1. DT 22-FEB-2023, entry version 18. DE SubName: Full=Spike protein {ECO:0000313|EMBL:AMR60845.1}; DE Flags: Fragment; GN Name=S {ECO:0000313|EMBL:AMR60845.1}; OS Porcine epidemic diarrhea virus. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Alphacoronavirus; Pedacovirus. OX NCBI_TaxID=28295 {ECO:0000313|EMBL:AMR60845.1}; RN [1] {ECO:0000313|EMBL:AMR60845.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CH-SCGA-2014 {ECO:0000313|EMBL:AMR60845.1}; RA Yang J., Yang X., Wang H.N.; RT "Sequence analysis of spike protein gene of porcine epidemic diarrhea virus RT isolated from Sichuan China during 2014-2015."; RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU975408; AMR60845.1; -; Genomic_RNA. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:InterPro. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:InterPro. DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro. DR GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:InterPro. DR Gene3D; 1.20.5.300; -; 2. DR InterPro; IPR043473; S2_sf_CoV. DR InterPro; IPR002552; Spike_S2_CoV. DR InterPro; IPR043614; Spike_S2_CoV_C. DR InterPro; IPR044873; Spike_S2_CoV_HR1. DR InterPro; IPR044874; Spike_S2_CoV_HR2. DR Pfam; PF01601; CoV_S2; 1. DR Pfam; PF19214; CoV_S2_C; 1. DR SUPFAM; SSF111474; Coronavirus S2 glycoprotein; 2. DR PROSITE; PS51923; COV_S2_HR1; 1. DR PROSITE; PS51924; COV_S2_HR2; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879}; KW Virion {ECO:0000256|ARBA:ARBA00022844}; KW Virulence {ECO:0000256|ARBA:ARBA00023026}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}. FT TRANSMEM 6..29 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 379..398 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 23..142 FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad FT repeat 1 (HR1) region profile" FT /evidence="ECO:0000259|PROSITE:PS51923" FT DOMAIN 294..390 FT /note="Coronavirus spike (S) glycoprotein S2 subunit heptad FT repeat 2 (HR2) region profile" FT /evidence="ECO:0000259|PROSITE:PS51924" FT COILED 320..357 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AMR60845.1" SQ SEQUENCE 437 AA; 48311 MW; 3908DFC049E6A20F CRC64; LHMYSASLIG GMVLGGFTSA AALPFSYAVQ ARLNYLALQT DVLQRNQQLL AESFNSAIGN ITSAFESVKE AISQTSKGLN TVAHALTKVQ EVVNSQGAAL TQLTVQLQHN FQAISSSIDD IYSRLDTLSA DVQVDRLITG RLSALNAFVA QTLTKYTEVQ ASRKLAQQKV NECVKSQSQR YGFCGGDGEH IFSLVQAAPQ GLLFLHTVLV PGDFVDVIAI AGLCVNDEIA LTLREPGLIL FTHELQNHTA TEYFVSSRRM FEPRKPTVSD FVQIESCVVT YVNLTRDQLP DVIPDYIDVN KTLDEILASL PNRTGPSLPL DVFNATYLNL TGEIADLEQR SESLRNTTEE LQSLISNINN TLVDLEWLNR VETYIKWPWW VWLIIFIVLI FVVSLLVFCC ISTGCCGCCG CCCACFSGCC RGPRLQPYEV FEKVHVQ //