ID A0A1P7U1M6_EBVA8 Unreviewed; 364 AA. AC A0A1P7U1M6; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 27-SEP-2017, entry version 6. DE RecName: Full=Triplex capsid protein 1 {ECO:0000256|HAMAP-Rule:MF_04018}; GN Name=TRX1 {ECO:0000256|HAMAP-Rule:MF_04018}; OS Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Gammaherpesvirinae; Lymphocryptovirus. OX NCBI_TaxID=82830 {ECO:0000313|Proteomes:UP000007639}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ABB89231.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AG876 {ECO:0000313|EMBL:ABB89231.1}; RX PubMed=16490228; DOI=10.1016/j.virol.2006.01.015; RA Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.; RT "The genome of Epstein-Barr virus type 2 strain AG876."; RL Virology 350:164-170(2006). RN [2] {ECO:0000313|EMBL:ABB89231.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AG876 {ECO:0000313|EMBL:ABB89231.1}; RA Dolan A., Addison C., Davison A.J., Rickinson A.B., McGeoch D.J.; RT "DNA sequence of Epstein-Barr virus type 2."; RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The CC capsid is composed of pentamers and hexamers of major capsid CC protein/MCP, which are linked together by heterotrimers called CC triplexes. These triplexes are formed by a single molecule of CC triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. CC Additionally, TRX1 is required for efficient transport of TRX2 to CC the nucleus, which is the site of capsid assembly. CC {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component CC 2/CVC2. {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|HAMAP-Rule:MF_04018}. CC Host nucleus {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family. CC {ECO:0000256|HAMAP-Rule:MF_04018}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ279927; ABB89231.1; -; Genomic_DNA. DR RefSeq; YP_001129451.1; NC_009334.1. DR GeneID; 5176167; -. DR KEGG; vg:5176167; -. DR Proteomes; UP000007639; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule. DR HAMAP; MF_04018; HSV_TRX1; 1. DR InterPro; IPR004999; Herpes_1. DR Pfam; PF03327; Herpes_VP19C; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|HAMAP-Rule:MF_04018}; KW Complete proteome {ECO:0000313|Proteomes:UP000007639}; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04018}; KW Reference proteome {ECO:0000313|Proteomes:UP000007639}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04018}. SQ SEQUENCE 364 AA; 39149 MW; C843A9B1A0C16152 CRC64; MKVQGSVDRR RLQRRIAGLL PPPARRLNIS RGSEFTRDVR GLVEEHAQAS SLSAAAVWRA GLLAPGEVAV AGGGSGGGSF SWSGWRPPVF GDFLIHASSF NNAEATGTPL FQFKQSDPFS GVDAVFTPLS LFILMNHGRG VAARVEAGGG LTRMANLLYD SPATLADLVP DFGRLVADRR FHNFITPVGP LVENIKSTYL NKITTVVHGP VVSKAIPRST VKVTVPQEAF VDLDAWLSGG AGGGGGGCFV GGLGLQPCPA DARLYVALTY EEAGPRFTFF QSSRGHCQIM NILRIYYSPS IMHRYAVVQP LHIEELTFGA VACLGTFSAT DGWRRSAFNY RGSSLPVVEI DSFYSNVSDW EVIL //